Bivalirudin Anticoagulation for an Infant with Hyperbilirubinemia and Elevated Plasma-Free Hemoglobin on ECMO.
bivalirudin
extracorporeal membrane oxygenation
heparin
heparin anti-Xa level
partial thromboplastin time
Journal
The journal of extra-corporeal technology
ISSN: 0022-1058
Titre abrégé: J Extra Corpor Technol
Pays: France
ID NLM: 0267637
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
03
08
2018
accepted:
21
11
2018
entrez:
3
4
2019
pubmed:
3
4
2019
medline:
27
4
2019
Statut:
ppublish
Résumé
Heparin has been used for decades as an anticoagulant in patients on mechanical circulatory support, which includes extracorporeal membrane oxygenation (ECMO) and ventricular assist devices. Bivalirudin is a direct thrombin inhibitor that can be used as an alternative anticoagulant in neonates and infants demonstrating inaccurate heparin monitoring. We report a case of a 2-month-old male child who was placed on ECMO for severe acute respiratory distress syndrome. His ECMO course was complicated by severe hemolysis and hyperbilirubinemia, which precluded accurate monitoring of heparin activity. Bivalirudin was successfully used for anticoagulation in this patient.
Substances chimiques
Anticoagulants
0
Hemoglobins
0
Hirudins
0
Peptide Fragments
0
Recombinant Proteins
0
Heparin
9005-49-6
bivalirudin
TN9BEX005G
Types de publication
Case Reports
Langues
eng
Pagination
26-28Références
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