Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study.
Aged
Carcinoma, Basal Cell
/ mortality
Carcinoma, Squamous Cell
/ mortality
Cohort Studies
Databases, Factual
Disease-Free Survival
Dose-Response Relationship, Radiation
Eyelid Neoplasms
/ mortality
Female
Hospitals, University
Humans
Hutchinson's Melanotic Freckle
/ mortality
Male
Melanoma
/ mortality
Middle Aged
Neoplasm Recurrence, Local
/ mortality
Prognosis
Radiotherapy Dosage
Retrospective Studies
Risk Assessment
Skin Neoplasms
/ mortality
Survival Analysis
Switzerland
Treatment Outcome
Periocular skin malignancies
Radiotherapy
Recurrence rate
Journal
Dermatology (Basel, Switzerland)
ISSN: 1421-9832
Titre abrégé: Dermatology
Pays: Switzerland
ID NLM: 9203244
Informations de publication
Date de publication:
2019
2019
Historique:
received:
13
08
2018
accepted:
27
12
2018
pubmed:
3
4
2019
medline:
18
12
2019
entrez:
3
4
2019
Statut:
ppublish
Résumé
Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge. To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors. Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi's sarcoma were included in the analysis. We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen's disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3-73). RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.
Sections du résumé
BACKGROUND
BACKGROUND
Due to the importance of function and cosmetics, periocular skin malignancies represent a therapeutic challenge.
OBJECTIVE
OBJECTIVE
To evaluate the safety and efficacy of radiotherapy (RT) treating periocular skin tumors.
METHODS
METHODS
Data of patients with periocular tumors treated with grenz or soft X-rays at the University Hospital Zurich, Switzerland, between 2009 and 2014 were reviewed. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) with associated in situ lesions, cutaneous melanoma, lentigo maligna (LM), cutaneous lymphoma and Kaposi's sarcoma were included in the analysis.
RESULTS
RESULTS
We found 159 periocular lesions in 145 patients. Overall recurrence was highest for actinic keratosis and Bowen's disease (27%), melanoma (17%) and LM (15%), whereas SCC and BCC showed recurrence in 11 and 10%, respectively. 45% of all recurrences occurred within 12 months after treatment, with a median time to recurrence of 13 months (range 3-73).
CONCLUSION
CONCLUSIONS
RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.
Identifiants
pubmed: 30939473
pii: 000496539
doi: 10.1159/000496539
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
234-239Informations de copyright
© 2019 S. Karger AG, Basel.