Retinoic acid signaling determines the fate of the uterus from the mouse Müllerian duct.
Müllerian ducts
Oviduct
Retinoic acid
Uterus
Vagina
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
13
11
2018
revised:
20
03
2019
accepted:
24
03
2019
pubmed:
4
4
2019
medline:
13
3
2020
entrez:
4
4
2019
Statut:
ppublish
Résumé
In female mice, the Müllerian duct develops into the oviduct, uterus and vagina. The fate of epithelia is determined by factors secreted from the mesenchyme. Retinoic acid (RA) and its receptors are present in the mesenchyme of cranial Müllerian duct. RA induces Müllerian duct to uterine epithelial differentiation whereas inhibition of RA receptors induces vaginal epithelial differentiation. Thus, RA signaling in the Müllerian duct is required to promote differentiation of the mesenchyme into the future uterus. Perinatal estrogen exposure induces various abnormalities in Müllerian duct-derived organs. These include a cranial shift of the border among oviduct, uterus and vagina as well as precancerous lesions suppressed by co-treatment with RA and estrogen. Since RA synthesis enzymes and receptors are expressed both in the epithelium and stroma after birth, RA signaling may act in the epithelia to maintain adult epithelial homeostasis and to prevent irreversible lesions induced by perinatal estrogen exposure.
Identifiants
pubmed: 30940504
pii: S0890-6238(18)30610-5
doi: 10.1016/j.reprotox.2019.03.006
pii:
doi:
Substances chimiques
Estrogens
0
Tretinoin
5688UTC01R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-61Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.