Envelope Protein Glycosylation Mediates Zika Virus Pathogenesis.
A549 Cells
Animals
Cell Adhesion Molecules
/ metabolism
Chlorocebus aethiops
Cytopathogenic Effect, Viral
/ genetics
Female
Flavivirus
/ metabolism
Glycosylation
Humans
Lectins, C-Type
/ metabolism
Male
Mice
Mice, Inbred C57BL
Receptors, Cell Surface
/ metabolism
Vero Cells
Viral Envelope Proteins
/ genetics
Virulence
Virus Replication
Zika Virus
/ genetics
Zika Virus Infection
/ virology
CD209
CD209L
DC-SIGN
DC-SIGNR
Ifnar1−/− mouse
L-SIGN
Zika virus
flavivirus
glycosylation
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 06 2019
15 06 2019
Historique:
received:
22
01
2019
accepted:
23
03
2019
pubmed:
5
4
2019
medline:
24
6
2020
entrez:
5
4
2019
Statut:
epublish
Résumé
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus. Recent ZIKV outbreaks have produced serious human disease, including neurodevelopmental malformations (congenital Zika syndrome) and Guillain-Barré syndrome. These outcomes were not associated with ZIKV infection prior to 2013, raising the possibility that viral genetic changes could contribute to new clinical manifestations. All contemporary ZIKV isolates encode an N-linked glycosylation site in the envelope (E) protein (N154), but this glycosylation site is absent in many historical ZIKV isolates. Here, we investigated the role of E protein glycosylation in ZIKV pathogenesis using two contemporary Asian-lineage strains (H/PF/2013 and PRVABC59) and the historical African-lineage strain (MR766). We found that glycosylated viruses were highly pathogenic in
Identifiants
pubmed: 30944176
pii: JVI.00113-19
doi: 10.1128/JVI.00113-19
pmc: PMC6613755
pii:
doi:
Substances chimiques
CLEC4M protein, human
0
Cell Adhesion Molecules
0
DC-specific ICAM-3 grabbing nonintegrin
0
Lectins, C-Type
0
Receptors, Cell Surface
0
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : P01 AI106695
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI129431
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007419
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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