Clostridium difficile infection: review.
Anti-Bacterial Agents
/ therapeutic use
Clostridioides difficile
/ drug effects
Clostridium Infections
/ diagnosis
Colitis
/ microbiology
Cross Infection
/ microbiology
Diarrhea
/ microbiology
Disease Reservoirs
/ microbiology
Fecal Microbiota Transplantation
Feces
/ microbiology
Humans
Risk Factors
Virulence
Antibiotic-associated diarrhea
Clostridium difficile
Diagnosis
Fecal transplantation
Treatment
Journal
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
27
01
2019
accepted:
12
03
2019
pubmed:
5
4
2019
medline:
15
11
2019
entrez:
5
4
2019
Statut:
ppublish
Résumé
Clostridium difficile (C. difficile) is a Gram-positive, spore-forming, anaerobic bacillus, which is widely distributed in the intestinal tract of humans and animals and in the environment. In the last decade, the frequency and severity of C. difficile infection has been increasing worldwide to become one of the most common hospital-acquired infections. Transmission of this pathogen occurs by the fecal-oral route and the most important risk factors include antibiotic therapy, old age, and hospital or nursing home stay. The clinical picture is diverse and ranges from asymptomatic carrier status, through various degrees of diarrhea, to the most severe, life threatening colitis resulting with death. Diagnosis is based on direct detection of C. difficile toxins in feces, most commonly with the use of EIA assay, but no single test is suitable as a stand-alone test confirming CDI. Antibiotics of choice are vancomycin, fidaxomicin, and metronidazole, though metronidazole is considered as inferior. The goal of this review is to update physicians on current scientific knowledge of C. difficile infection, focusing also on fecal microbiota transplantation which is a promising therapy.
Identifiants
pubmed: 30945014
doi: 10.1007/s10096-019-03539-6
pii: 10.1007/s10096-019-03539-6
pmc: PMC6570665
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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