Intravenous immunoglobulin suppresses the polarization of both classically and alternatively activated macrophages.
IVIG
IgG
inflammation
innate cells
macrophage
monocyte
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
5
4
2019
medline:
22
6
2021
entrez:
5
4
2019
Statut:
ppublish
Résumé
Intravenous immunoglobulin (IVIG) is one of the widely used immunotherapeutic molecules in the therapy of autoimmune and inflammatory diseases. Previous reports demonstrate that one of the anti-inflammatory actions of IVIG implicates suppression of macrophage activation and release of their inflammatory mediators. However, macrophages are highly plastic and depending on the microenvironmental signals, macrophages can be polarized into pro-inflammatory classic (M1) or anti-inflammatory alternative (M2) type. This plasticity of macrophages raised additional questions on the role of IVIG towards macrophage polarization. In the present report, we show that IVIG affects the polarization of both classically and alternatively activated macrophages and this process is F(ab')
Identifiants
pubmed: 30945973
doi: 10.1080/21645515.2019.1602434
pmc: PMC7062444
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Immunoglobulins, Intravenous
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-239Références
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