Intratumoral platelet aggregate formation in a murine preclinical glioma model depends on podoplanin expression on tumor cells.
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
received:
08
01
2018
accepted:
17
02
2019
entrez:
6
4
2019
pubmed:
6
4
2019
medline:
24
7
2020
Statut:
ppublish
Résumé
Binding of the sialomucin-like transmembrane glycoprotein podoplanin (PDPN) to the platelet receptor C-type lectin-like receptor 2 induces platelet activation and aggregation. In human high-grade gliomas, PDPN is highly expressed both in tumor cells and in tumor-associated astrocytes. In glioma patients, high expression of PDPN is associated with worse prognosis and has been shown to correlate with intratumoral platelet aggregation and an increased risk of venous thromboembolism (VTE). To functionally assess the role of PDPN in platelet aggregation in vivo, we established a syngeneic orthotopic murine glioma model in C57/Bl6 mice, based on transplantation of
Identifiants
pubmed: 30948364
pii: bloodadvances.2018015966
doi: 10.1182/bloodadvances.2018015966
pmc: PMC6457221
doi:
Substances chimiques
Gp38 protein, mouse
0
Membrane Glycoproteins
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
PTEN Phosphohydrolase
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1092-1102Informations de copyright
© 2019 by The American Society of Hematology.
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