One-year single-center experience with the Aperio thrombectomy device in large vessel occlusion in the anterior circulation: safety, efficacy, and clinical outcome.
Aperio thrombectomy device
Clinical outcome
Ischemic stroke
M1 segment occlusion
Thrombectomy
Journal
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
ISSN: 1590-3478
Titre abrégé: Neurol Sci
Pays: Italy
ID NLM: 100959175
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
09
10
2018
accepted:
20
03
2019
pubmed:
6
4
2019
medline:
14
1
2020
entrez:
6
4
2019
Statut:
ppublish
Résumé
The Aperio thrombectomy device (Aperio) is a stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke due to large-vessel occlusions (LVOs). We evaluated the safety and efficacy of the Aperio device and compared it with published data of established stent retrievers. We retrospectively analyzed institutional data of consecutive stroke procedures in patients with LVO in the anterior circulation that were treated between January 2017 and December 2017 with the Aperio. Reperfusion rate regarding to the extended thrombolysis in cerebral infarction scale (eTICI), procedural times, early clinical outcome, and complications were documented. Eighty-two patients were treated by using the Aperio in LVO in the anterior circulation. Median age was 77 (± 12) years (w = 59.8%). Median Baseline National Institutes of Health Stroke Scale (NIHSS) score was 14. Fifty-three (64.6%) patients received intravenous thrombolysis. Successful recanalization (eTICI≥2b) was achieved in 85.3%. Mean time from groin puncture to final recanalization was 52.3 ± 34.8 min. Embolization to new territories occurred in one case. Symptomatic intracranial hemorrhage within 24 h was observed in six patients (7.3%). Twenty-eight (41.2%) out of 68 patients available for assessment of functional outcome at 3 months achieved favorable outcome (mRS 0-2). The Aperio stent retriever mechanical thrombectomy device demonstrated high rates of successful reperfusion and a good safety profile in patients with acute ischemic stroke due to LVO in the anterior circulation.
Sections du résumé
BACKGROUND AND PURPOSE
OBJECTIVE
The Aperio thrombectomy device (Aperio) is a stent retriever designed to achieve rapid and substantial flow restoration in acute ischemic stroke due to large-vessel occlusions (LVOs). We evaluated the safety and efficacy of the Aperio device and compared it with published data of established stent retrievers.
METHODS
METHODS
We retrospectively analyzed institutional data of consecutive stroke procedures in patients with LVO in the anterior circulation that were treated between January 2017 and December 2017 with the Aperio. Reperfusion rate regarding to the extended thrombolysis in cerebral infarction scale (eTICI), procedural times, early clinical outcome, and complications were documented.
RESULTS
RESULTS
Eighty-two patients were treated by using the Aperio in LVO in the anterior circulation. Median age was 77 (± 12) years (w = 59.8%). Median Baseline National Institutes of Health Stroke Scale (NIHSS) score was 14. Fifty-three (64.6%) patients received intravenous thrombolysis. Successful recanalization (eTICI≥2b) was achieved in 85.3%. Mean time from groin puncture to final recanalization was 52.3 ± 34.8 min. Embolization to new territories occurred in one case. Symptomatic intracranial hemorrhage within 24 h was observed in six patients (7.3%). Twenty-eight (41.2%) out of 68 patients available for assessment of functional outcome at 3 months achieved favorable outcome (mRS 0-2).
CONCLUSION
CONCLUSIONS
The Aperio stent retriever mechanical thrombectomy device demonstrated high rates of successful reperfusion and a good safety profile in patients with acute ischemic stroke due to LVO in the anterior circulation.
Identifiants
pubmed: 30949780
doi: 10.1007/s10072-019-03861-z
pii: 10.1007/s10072-019-03861-z
doi:
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1443-1451Références
Stroke. 1999 Nov;30(11):2280-4
pubmed: 10548658
AJNR Am J Neuroradiol. 2009 Mar;30(3):525-31
pubmed: 19147716
Lancet. 2012 Oct 6;380(9849):1231-40
pubmed: 22932714
Int J Stroke. 2014 Jul;9(5):658-68
pubmed: 23130938
J Neurointerv Surg. 2014 Oct;6(8):584-8
pubmed: 24062252
Cerebrovasc Dis. 2013;36(5-6):437-45
pubmed: 24281318
J Neurointerv Surg. 2015 Feb;7(2):90-4
pubmed: 24463439
N Engl J Med. 2015 Jan 1;372(1):11-20
pubmed: 25517348
N Engl J Med. 2015 Mar 12;372(11):1009-18
pubmed: 25671797
N Engl J Med. 2015 Jun 11;372(24):2285-95
pubmed: 25882376
N Engl J Med. 2015 Jun 11;372(24):2296-306
pubmed: 25882510
Stroke. 2015 Oct;46(10):3020-35
pubmed: 26123479
J Neurointerv Surg. 2016 Aug;8(8):834-9
pubmed: 26220408
Stroke. 2016 Mar;47(3):798-806
pubmed: 26888532
Lancet. 2016 Apr 23;387(10029):1723-31
pubmed: 26898852
J Neurointerv Surg. 2017 Apr;9(4):346-351
pubmed: 27056920
Clin Neuroradiol. 2018 Sep;28(3):327-338
pubmed: 28194477
JAMA. 2017 Aug 1;318(5):443-452
pubmed: 28763550
J Neurointerv Surg. 2018 Jun;10(6):516-524
pubmed: 28963367
N Engl J Med. 2018 Jan 4;378(1):11-21
pubmed: 29129157
J Neurointerv Surg. 2018 Aug;10(8):751-755
pubmed: 29222393
Stroke. 2018 Mar;49(3):660-666
pubmed: 29459390
J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):910-917
pubmed: 29519899
J Neurointerv Surg. 2018 Oct;10(10):964-968
pubmed: 29574421
Stroke. 2018 May;49(5):1107-1115
pubmed: 29643261
Medicine (Baltimore). 2018 May;97(20):e10747
pubmed: 29768352
J Neurointerv Surg. 2019 Jan;11(1):9-13
pubmed: 29802163