Influence of the construction of porous spargers on lovastatin production by Aspergillus terreus ATCC 20,542 in a laboratory bubble column.
Aspergillus terreus
Bubble column bioreactor
Lovastatin
sparger design
Journal
Bioprocess and biosystems engineering
ISSN: 1615-7605
Titre abrégé: Bioprocess Biosyst Eng
Pays: Germany
ID NLM: 101088505
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
13
02
2019
accepted:
27
03
2019
revised:
24
03
2019
pubmed:
6
4
2019
medline:
19
12
2019
entrez:
6
4
2019
Statut:
ppublish
Résumé
In bubble column bioreactors, the hydrodynamic behavior like mixing time, bubble size and morphology of filamentous fungi are influenced by the construction of spargers. Sparger pore size is an important factor influencing formation of bubbles. In this study for the first time, a 5-L bubble column bioreactor with different porous spargers was used to investigate the effect of mean air bubble diameter (at 0.36, 0.18 and 0.09 cm) on fungal growth, broth viscosity, fungal pellet morphology and lovastatin production by the filamentous fungus Aspergillus terreus. All cultivations were carried out at air flow rate equal to 0.5 L
Identifiants
pubmed: 30949844
doi: 10.1007/s00449-019-02118-5
pii: 10.1007/s00449-019-02118-5
doi:
Substances chimiques
Lovastatin
9LHU78OQFD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM