Mobile technology offers novel insights into the control and treatment of allergic rhinitis: The MASK study.


Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
07 2019
Historique:
received: 12 11 2018
revised: 05 01 2019
accepted: 23 01 2019
pubmed: 6 4 2019
medline: 19 5 2020
entrez: 6 4 2019
Statut: ppublish

Résumé

Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR. A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.

Sections du résumé

BACKGROUND
Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control.
OBJECTIVES
A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity in the everyday life of patients with AR.
METHODS
A mobile phone app (Allergy Diary, which is freely available on Google Play and Apple stores) was used to collect the data of daily visual analogue scale (VAS) scores for (1) overall allergic symptoms; (2) nasal, ocular, and asthma symptoms; (3) work; and (4) medication use by using a treatment scroll list including all allergy medications (prescribed and over-the-counter) customized for 22 countries. The 4 most common intranasal medications containing intranasal corticosteroids and 8 oral H
RESULTS
Nine thousand one hundred twenty-two users filled in 112,054 days of VASs in 2016 and 2017. Assessment of days was informative. Control of days with rhinitis differed between no (best control), single (good control for intranasal corticosteroid-treated days), or multiple (worst control) treatments. Users with the worst control increased the range of treatments being used. The same trend was found for asthma, eye symptoms, and work productivity. Differences between oral H
CONCLUSIONS
This study confirms the usefulness of the Allergy Diary in accessing and assessing behavior in patients with AR. This observational study using a very simple assessment tool (VAS) on a mobile phone had the potential to answer questions previously thought infeasible.

Identifiants

pubmed: 30951790
pii: S0091-6749(19)30426-9
doi: 10.1016/j.jaci.2019.01.053
pii:
doi:

Substances chimiques

Adrenal Cortex Hormones 0
Histamine H1 Antagonists 0

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

135-143.e6

Informations de copyright

Copyright © 2019 American Academy of Allergy, Asthma & Immunology. All rights reserved.

Auteurs

Annabelle Bédard (A)

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Xavier Basagaña (X)

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Josep M Anto (JM)

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Judith Garcia-Aymerich (J)

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Philippe Devillier (P)

UPRES EA220, Pôle des Maladies des Voies Respiratoires, Hôpital Foch, Université Paris-Saclay, Suresnes, France.

Sylvie Arnavielhe (S)

KYomed INNOV, Montpellier, France.

Anna Bedbrook (A)

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Gabrielle L Onorato (GL)

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France.

Wienczyslawa Czarlewski (W)

Medical Consulting Czarlewski, Levallois, France.

Ruth Murray (R)

Medical Communications Consultant, MedScript, Dundalk, and OPC, Cambridge, United Kingdom.

Rute Almeida (R)

Center for Health Technology and Services Research-CINTESIS, Faculdade de Medicina, Universidade do Porto, and Medida, Porto, Portugal.

Joao Fonseca (J)

Center for Health Technology and Services Research-CINTESIS, Faculdade de Medicina, Universidade do Porto, and Medida, Porto, Portugal.

Elisio Costa (E)

UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Active and Healthy Ageing of University of Porto (Porto4Ageing), Porto, Portugal.

Joao Malva (J)

Institute of Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, and the Ageing@Coimbra EIP-AHA Reference Site, Coimbra, Portugal.

Mario Morais-Almeida (M)

Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal.

Ana Margarida Pereira (AM)

Allergy Unit, CUF-Porto Hospital and Institute, and the Center for Research in Health Technologies and information systems CINTESIS, Universidade do Porto, Porto, Portugal.

Ana Todo-Bom (A)

Imunoalergologia, Centro Hospitalar Universitário de Coimbra and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Enrica Menditto (E)

CIRFF, Federico II University, Naples, Italy.

Cristiana Stellato (C)

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

Maria Teresa Ventura (MT)

Unit of Geriatric Immunoallergology, University of Bari Medical School, Bari, Italy.

Alvaro A Cruz (AA)

ProAR-Nucleo de Excelencia em Asma, Federal University of Bahia, and the WHO GARD Planning Group, Brazil.

Rafaël Stelmach (R)

Pulmonary Division, Heart Institute (InCor), Hospital da Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.

Jane da Silva (J)

Department of Internal Medicine and Allergy Clinic of Professor Polydoro Ernani de São Thiago University Hospital, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil.

Désirée Larenas-Linnemann (D)

Center of Excellence in Asthma and Allergy, Hospital Médica Sur, México City, Mexico.

José M Fuentes-Pérez (JM)

Hospital General Region 1, Dr Carlos Mc Gregor Sanchez Navarro" IMSS, Mexico City, Mexico.

Yunuen R Huerta-Villalobos (YR)

Hospital General Region 1, Dr Carlos Mc Gregor Sanchez Navarro" IMSS, Mexico City, Mexico.

Regina Emuzyte (R)

Clinic of Children's Diseases, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Violeta Kvedariene (V)

Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Arunas Valiulis (A)

Vilnius University Institute of Clinical Medicine, Clinic of Children's Diseases, and the Institute of Health Sciences, Department of Public Health, Vilnius, Lithuania; European Academy of Paediatrics (EAP/UEMS-SP), Brussels, Belgium.

Piotr Kuna (P)

Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland.

Boleslaw Samolinski (B)

Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.

Ludger Klimek (L)

Center for Rhinology and Allergology, Wiesbaden, Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Ralph Mösges (R)

Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany.

Oliver Pfaar (O)

Department of Otorhinolaryngology, Head and Neck Surgery, Section for Rhinology and Allergy, University Hospital Marburg, Phillipps-Universität, Marburg, Germany.

Sara Shamai (S)

Institute of Medical Statistics, and Computational Biology, Medical Faculty, University of Cologne, and CRI-Clinical Research International, Hamburg, Germany.

Isabelle Annesi-Maesano (I)

Epidemiology of Allergic and Respiratory Diseases, Department Institute Pierre Louis of Epidemiology and Public Health, INSERM and UPMC Sorbonne Université, Medical School Saint Antoine, Paris, France.

Isabelle Bosse (I)

Allergist, La Rochelle, France.

Pascal Demoly (P)

Department of Respiratory Diseases, Montpellier University Hospital, Montpellier, France.

Jean-François Fontaine (JF)

Allergist, Reims, France.

Vicky Cardona (V)

Allergy Section, Department of Internal Medicine, Hospital Vall'dHebron & ARADyAL Research Network, Barcelona, Spain.

Joaquim Mullol (J)

Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES, University of Barcelona, Barcelona, Spain.

Antonio Valero (A)

Pneumology and Allergy Department CIBERES and Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, University of Barcelona, Barcelona, Spain.

Regina E Roller-Wirnsberger (RE)

Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Peter Valentin Tomazic (PV)

Department of ENT, Medical University of Graz, Graz, Austria.

Niels H Chavannes (NH)

Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.

Wytske J Fokkens (WJ)

Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands.

Sietze Reitsma (S)

Department of Otorhinolaryngology, Amsterdam University Medical Centres, AMC, Amsterdam, the Netherlands.

Mike Bewick (M)

iQ4U Consultants, London, United Kingdom.

Dermot Ryan (D)

Allergy and Respiratory Research Group, University of Edinburgh, Edinburgh, United Kingdom.

Aziz Sheikh (A)

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom.

Tari Haahtela (T)

Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

Sanna Toppila-Salmi (S)

Skin and Allergy Hospital, Helsinki University Hospital, Helsinki, Finland.

Erkka Valovirta (E)

Department of Lung Diseases and Clinical Immunology, University of Turku and Terveystalo allergy clinic, Turku, Finland.

Michael Makris (M)

Allergy Unit "D Kalogeromitros", 2nd Department of Dermatology and Venereology, National & Kapodistrian University of Athens, "Attikon" University Hospital, Athens, Greece.

Nikos G Papadopoulos (NG)

Center for Pediatrics and Child Health, Institute of Human Development, Royal Manchester Children's Hospital, University of Manchester, and UK Allergy Department, 2nd Pediatric Clinic, Athens General Children's Hospital "P&A Kyriakou", University of Athens, Athens, Greece.

Emmanuel P Prokopakis (EP)

Department of Otorhinolaryngology University of Crete School of Medicine, Heraklion, Greece.

Fotis Psarros (F)

Allergy Department, Athens Naval Hospital, Athens, Greece.

Cemal Cingi (C)

Eskisehir Osmangazi University, Medical Faculty, ENT Department, Eskisehir, Turkey.

Bilun Gemicioğlu (B)

Department of Pulmonary Diseases, Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Arzu Yorgancioglu (A)

Department of Pulmonary Diseases, Celal Bayar University, Faculty of Medicine, Manisa (and the GARD Executive Committee), Manisa, Turkey.

Sinthia Bosnic-Anticevich (S)

Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; Woolcock Emphysema Centre and Local Health District, Glebe, Australia.

Robyn E O'Hehir (RE)

Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Central Clinical School, and the Department of Immunology, Monash University, Melbourne, Australia.

Claus Bachert (C)

Upper Airways Research Laboratory, ENT Department, Ghent University Hospital, Ghent, Belgium.

Peter W Hellings (PW)

Department of Otorhinolaryngology, University Hospitals Leuven, and the Academic Medical Center, University of Amsterdam, and Euforea, Brussels, Belgium.

Benoit Pugin (B)

European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Brussels, Belgium.

Carsten Bindslev-Jensen (C)

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark.

Esben Eller (E)

Department of Dermatology and Allergy Centre, Odense University Hospital, Odense Research Center for Anaphylaxis (ORCA), Odense, Denmark.

Ingrid Kull (I)

Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, and Sach's Children and Youth Hospital, Södersjukhuset, Stockholm, Sweden; Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Erik Melén (E)

Sachs' Children and Youth Hospital, Södersjukhuset, Stockholm and Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Magnus Wickman (M)

Centre for Clinical Research Sörmland, Uppsala University, Eskilstuna, Sweden.

Gert De Vries (G)

Peercode BV, Geldermalsen, the Netherlands.

Michiel van Eerd (M)

Peercode BV, Geldermalsen, the Netherlands.

Ioana Agache (I)

Transylvania University Brasov, Brasov, Romania.

Ignacio J Ansotegui (IJ)

Department of Allergy and Immunology, Hospital Quirón Bizkaia, Erandio, Spain.

Mark S Dykewicz (MS)

Section of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Mo.

Thomas Casale (T)

Division of Allergy/Immunology, University of South Florida, Tampa, Fla.

Dana Wallace (D)

Nova Southeastern University, Fort Lauderdale, Fla.

Susan Waserman (S)

Department of Medicine, Clinical Immunology and Allergy, McMaster University, Hamilton, Ontario, Canada.

Daniel Laune (D)

KYomed INNOV, Montpellier, France.

Jean Bousquet (J)

MACVIA-France, Fondation partenariale FMC VIA-LR, Montpellier, France; University Hospital, Montpellier, France; INSERM U 1168, VIMA: Ageing and chronic diseases Epidemiological and Public Health Approaches, Villejuif, Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, and Euforea, Brussels, Belgium. Electronic address: jean.bousquet@orange.f.

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