Age-related differences in frontal lobe function in children with ADHD.
Age Factors
Attention Deficit Disorder with Hyperactivity
/ diagnostic imaging
Brain Mapping
/ methods
Child
Executive Function
/ physiology
Female
Frontal Lobe
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
/ methods
Magnetic Resonance Imaging
/ methods
Male
Prefrontal Cortex
/ diagnostic imaging
Spectroscopy, Near-Infrared
/ methods
Attention deficit hyperactivity disorder (ADHD)
Children with ADHD
Frontal lobe function
Inhibitory control
Near-infrared spectroscopy (NIRS)
Prefrontal cortex (PFC)
Reverse Stroop task (RST)
Journal
Brain & development
ISSN: 1872-7131
Titre abrégé: Brain Dev
Pays: Netherlands
ID NLM: 7909235
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
31
08
2018
revised:
13
03
2019
accepted:
14
03
2019
pubmed:
7
4
2019
medline:
7
1
2020
entrez:
7
4
2019
Statut:
ppublish
Résumé
The neural correlates of executive function disorders are thought to be predominantly localized within the prefrontal cortex (PFC). However, no study to date has investigated changes in this system across different age groups in children with attention deficit hyperactivity disorder (ADHD). Thus, this study aimed to explore changes in PFC function in children with ADHD. Study participants included typically developing (TD) children (n = 140) and children with ADHD (n = 67) of primary school age. Behavioral executive functions and their neural basis were evaluated between the TD children and children with ADHD and also across different age periods (younger and older children). To examine executive function, inhibitory control was assessed using the reverse Stroop task, and PFC near-infrared spectroscopic measurements were used to investigate the neural mechanisms involved. Both ADHD symptoms and the ability to inhibit color interference improved with age. Compared to TD children, children with ADHD demonstrated decreased activation of the right and middle PFC across all age groups. Interestingly, the left PFC appeared to play a compensatory role. Children with ADHD exhibited changes in PFC function that varied with age. Longitudinal studies are required to assess the potential of using PFC function as an early biomarker of ADHD.
Sections du résumé
BACKGROUND
BACKGROUND
The neural correlates of executive function disorders are thought to be predominantly localized within the prefrontal cortex (PFC). However, no study to date has investigated changes in this system across different age groups in children with attention deficit hyperactivity disorder (ADHD). Thus, this study aimed to explore changes in PFC function in children with ADHD.
METHODS
METHODS
Study participants included typically developing (TD) children (n = 140) and children with ADHD (n = 67) of primary school age. Behavioral executive functions and their neural basis were evaluated between the TD children and children with ADHD and also across different age periods (younger and older children). To examine executive function, inhibitory control was assessed using the reverse Stroop task, and PFC near-infrared spectroscopic measurements were used to investigate the neural mechanisms involved.
RESULTS
RESULTS
Both ADHD symptoms and the ability to inhibit color interference improved with age. Compared to TD children, children with ADHD demonstrated decreased activation of the right and middle PFC across all age groups. Interestingly, the left PFC appeared to play a compensatory role.
CONCLUSION
CONCLUSIONS
Children with ADHD exhibited changes in PFC function that varied with age. Longitudinal studies are required to assess the potential of using PFC function as an early biomarker of ADHD.
Identifiants
pubmed: 30952459
pii: S0387-7604(18)30436-4
doi: 10.1016/j.braindev.2019.03.006
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-586Informations de copyright
Copyright © 2019 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.