Time-restricted Feeding Attenuates High-fat Diet-enhanced Spontaneous Metastasis of Lewis Lung Carcinoma in Mice.
Adipokines
/ blood
Adiposity
Angiogenic Proteins
/ blood
Animals
Blood Glucose
/ metabolism
Carcinoma, Lewis Lung
/ blood
Circadian Rhythm Signaling Peptides and Proteins
/ genetics
Cytokines
/ blood
Diet, High-Fat
/ adverse effects
Fasting
Inflammation Mediators
/ blood
Insulin
/ blood
Lung Neoplasms
/ blood
Male
Mice, Inbred C57BL
Obesity
/ blood
Time Factors
Weight Gain
Lewis lung carcinoma
Time-restricted feeding
high-fat diet
metastasis
mice
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
17
02
2019
revised:
06
03
2019
accepted:
08
03
2019
entrez:
7
4
2019
pubmed:
7
4
2019
medline:
24
4
2019
Statut:
ppublish
Résumé
Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis. In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male C57BL/6 mice were fed the standard AIN93G diet or a high-fat diet (HFD) with or without dark-phase restricted feeding (12 h per day) for 10 weeks. Pulmonary metastases from a subcutaneous tumor were quantified. The number and size of lung metastases were greater in the HFD group than in the AIN93G group, but did not differ between the TRF and AIN93G groups. TRF prevented HFD-induced increases in plasma concentrations of glucose, insulin, proinflammatory cytokines (leptin, monocyte chemotactic protein-1, plasminogen activator inhibitor-1), and angiogenic factors (angiopoietin-2, hepatic growth factor, vascular endothelial growth factor). TRF attenuates the HFD-enhanced spontaneous metastasis of LLC in mice.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
Obesity is a risk factor for cancer. Disruption of the daily feeding and fasting rhythm can contribute to obesity. This study tested the hypothesis that time-restricted feeding (TRF) attenuates obesity-enhanced metastasis.
MATERIALS AND METHODS
METHODS
In a spontaneous metastasis model of Lewis lung carcinoma (LLC), male C57BL/6 mice were fed the standard AIN93G diet or a high-fat diet (HFD) with or without dark-phase restricted feeding (12 h per day) for 10 weeks. Pulmonary metastases from a subcutaneous tumor were quantified.
RESULTS
RESULTS
The number and size of lung metastases were greater in the HFD group than in the AIN93G group, but did not differ between the TRF and AIN93G groups. TRF prevented HFD-induced increases in plasma concentrations of glucose, insulin, proinflammatory cytokines (leptin, monocyte chemotactic protein-1, plasminogen activator inhibitor-1), and angiogenic factors (angiopoietin-2, hepatic growth factor, vascular endothelial growth factor).
CONCLUSION
CONCLUSIONS
TRF attenuates the HFD-enhanced spontaneous metastasis of LLC in mice.
Identifiants
pubmed: 30952713
pii: 39/4/1739
doi: 10.21873/anticanres.13280
doi:
Substances chimiques
Adipokines
0
Angiogenic Proteins
0
Blood Glucose
0
Circadian Rhythm Signaling Peptides and Proteins
0
Cytokines
0
Inflammation Mediators
0
Insulin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1739-1748Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.