Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
13
10
2017
accepted:
11
03
2019
pubmed:
7
4
2019
medline:
31
12
2019
entrez:
7
4
2019
Statut:
ppublish
Résumé
Biliverdin reductase (BVR)-A is a pleotropic enzyme converting biliverdin to bilirubin and a signaling molecule that has cytoprotective and immunomodulatory effects. We recently showed that biliverdin inhibits the expression of complement activation fragment 5a receptor one (C5aR1) in RAW 264.7 macrophages. In this study, we investigated the role of BVR-A in determining macrophage inflammatory phenotype and function via regulation of C5aR1. We assessed expression of C5aR1, M1-like macrophage markers, including chemokines (RANTES, IP-10), as well as chemotaxis in response to LPS and C5a in bone marrow-derived macrophages from
Identifiants
pubmed: 30952817
pii: jimmunol.1701443
doi: 10.4049/jimmunol.1701443
pmc: PMC6504595
mid: NIHMS1524242
doi:
Substances chimiques
C5ar1 protein, mouse
0
Chemokines
0
Receptor, Anaphylatoxin C5a
0
Complement C5a
80295-54-1
Oxidoreductases Acting on CH-CH Group Donors
EC 1.3.-
biliverdin reductase
EC 1.3.1.24
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2982-2990Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK104714
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA169904
Pays : United States
Informations de copyright
Copyright © 2019 by The American Association of Immunologists, Inc.
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