Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 04 2019
05 04 2019
Historique:
received:
11
09
2018
accepted:
14
03
2019
entrez:
7
4
2019
pubmed:
7
4
2019
medline:
10
5
2019
Statut:
epublish
Résumé
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10
Identifiants
pubmed: 30952852
doi: 10.1038/s41467-019-09576-1
pii: 10.1038/s41467-019-09576-1
pmc: PMC6451011
doi:
Substances chimiques
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
1585Subventions
Organisme : British Heart Foundation
ID : RG/16/11/32334
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M005070/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S011676/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P012167/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK105072
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL136884
Pays : United States
Organisme : Medical Research Council
ID : MR/R024227/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK107859
Pays : United States
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