microRNA expression profiles in two- and three-dimensional culture conditions of human-umbilical-cord blood-derived CD34
Antigens, CD34
/ metabolism
Cell Culture Techniques
/ methods
Cell Differentiation
/ physiology
Cell Proliferation
/ physiology
Cells, Cultured
Feeder Cells
/ metabolism
Fetal Blood
/ metabolism
Hematopoiesis
/ physiology
Hematopoietic Stem Cells
/ metabolism
Humans
Mesenchymal Stem Cells
/ metabolism
MicroRNAs
/ metabolism
Nanofibers
/ chemistry
human-umbilical-cord blood-derived CD34+ cells
microRNAs
polyethersulfone nanofiber
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
13
03
2019
accepted:
19
03
2019
pubmed:
7
4
2019
medline:
30
5
2020
entrez:
7
4
2019
Statut:
ppublish
Résumé
Human umbilical cord blood (HUCB) is a suitable source of hematopoietic stem cells (HSCs) for therapeutic transplantation. Different approaches have been used to expand the number of HSCs to increase the rate of HSC transplantation success in patients, such as using different cocktails of cytokines, feeder cell layers, and biocompatible scaffolds. microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression posttranscriptionally. They play crucial roles in hematopoiesis including stem cell proliferation, differentiation, stemness, and self-renewal properties. Here, we studied the UCB-derived CD34
Substances chimiques
Antigens, CD34
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20072-20084Informations de copyright
© 2019 Wiley Periodicals, Inc.