Benchmarking of a checklist for the identification of familial risk for breast and ovarian cancers in a prospective cohort.
BRCA1
BRCA2
breast cancer
familial risk
genetic testing
Journal
The breast journal
ISSN: 1524-4741
Titre abrégé: Breast J
Pays: United States
ID NLM: 9505539
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
14
08
2018
revised:
16
08
2018
accepted:
22
08
2018
pubmed:
7
4
2019
medline:
27
12
2019
entrez:
7
4
2019
Statut:
ppublish
Résumé
The detection of deleterious germline mutations in BRCA1 and BRCA2 considerably influences the clinical management of healthy and diseased carriers. Therefore, the identification of persons at risk who could uptake genetic counseling and testing is pivotal. We developed a checklist with validated criteria to improve the identification, and prospectively evaluate the incidence, of familial cancer history in 5091 breast cancer patients. The rate of 30.4% of patients at high genetic risk underpins the demand for care in risk identification and counseling. The easy-to-use instrument promotes the implementation and dissemination of risk counseling by physicians.
Substances chimiques
BRCA1 Protein
0
BRCA1 protein, human
0
BRCA2 Protein
0
BRCA2 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-460Informations de copyright
© 2019 Wiley Periodicals, Inc.