Oxytocin administration modulates rats' helping behavior depending on social context.
Empathy
Oxytocin
Prosocial behavior
Rats
Journal
Neuroscience research
ISSN: 1872-8111
Titre abrégé: Neurosci Res
Pays: Ireland
ID NLM: 8500749
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
11
01
2019
revised:
19
03
2019
accepted:
02
04
2019
pubmed:
7
4
2019
medline:
30
1
2021
entrez:
7
4
2019
Statut:
ppublish
Résumé
The affiliative effect of oxytocin on behavior toward other individuals can be modulated by positive and negative aspects of those individuals. However, the context-dependent effect of oxytocin on helping behavior is still unclear. In this study, we examined the effect of oxytocin administration on helping behavior in rats. The rats learned to open a door to help a cagemate soaked with water. The rats were divided into Pair and Solo groups. The rats in the Pair group were housed with their cagemates and those in the Solo group were housed individually. The rats in both groups received oxytocin (1.0 mg/kg) or saline injections intraperitoneally for 5 consecutive days before starting the experimental sessions. In the rats injected with oxytocin, the Solo group showed helping behavior faster than those in the Pair group. The results suggest that the effects of oxytocin administration on helping behavior are dependent on the social context.
Identifiants
pubmed: 30953682
pii: S0168-0102(19)30017-3
doi: 10.1016/j.neures.2019.04.001
pii:
doi:
Substances chimiques
Oxytocin
50-56-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
56-61Informations de copyright
Copyright © 2019 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.