Panitins A-G: Coumarin derivatives from Murraya paniculata from Guangxi Province, China show variable NO inhibitory activity.

Cell Line Coumarins / chemistry Microglia / drug effects Models, Molecular Molecular Conformation Murraya / chemistry Nitric Oxide / antagonists & inhibitors Plant Roots / chemistry
Coumarin dimers Coumarins Murraya paniculata (L.) Jack NO inhibition Rutaceae

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jun 2019
Historique:
received: 13 10 2018
revised: 15 03 2019
accepted: 16 03 2019
pubmed: 7 4 2019
medline: 17 5 2019
entrez: 7 4 2019
Statut: ppublish

Résumé

Seven previously undescribed coumarin derivatives, panitins A‒G, an ethoxylated artifact, and 34 known analogues, were isolated from the roots of Murraya paniculata. Their structures were elucidated on the basis of comprehensive analysis of 1D and 2D NMR and HRMS spectroscopic data, and comparison with the data reported in literature. The absolute configurations of undescribed compounds were assigned via comparison of the specific rotation, Mosher's method, exciton chiral method, and comparison of calculated and experimental ECD data. Panitin D, trans-dehydroosthol, and exotimarin I showed potent inhibition against LPS-induced NO production in BV-2 microglial cells with IC

Identifiants

DOI: 10.1016/j.phytochem.2019.03.012 PMID: 30953909
pubmed: 30953909
pii: S0031-9422(18)30653-8
doi: 10.1016/j.phytochem.2019.03.012
pii:
doi:

Substances chimiques

Coumarins 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

224-231

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Xiaoting Wang (X)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Haizhen Liang (H)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Kewu Zeng (K)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Mingbo Zhao (M)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Pengfei Tu (P)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.

Jun Li (J)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: lijun@bjmu.edu.cn.

Yong Jiang (Y)

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China. Electronic address: yongjiang@bjmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Coumarines › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Murraya › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › Panitins A-G: Coumarin derivatives from...
questionsmedicales.fr › Structures de plante › Racines de plante › Panitins A-G: Coumarin derivatives from...