Ferritin regulates organismal energy balance and thermogenesis.
Adipose tissue
Energy expenditure
Iron metabolism
Mitochondria
Redox homeostasis
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
03
01
2019
revised:
13
03
2019
accepted:
15
03
2019
pubmed:
8
4
2019
medline:
16
4
2020
entrez:
8
4
2019
Statut:
ppublish
Résumé
The ferritin heavy/heart chain (FTH) gene encodes the ferroxidase component of the iron (Fe) sequestering ferritin complex, which plays a central role in the regulation of cellular Fe metabolism. Here we tested the hypothesis that ferritin regulates organismal Fe metabolism in a manner that impacts energy balance and thermal homeostasis. We developed a mouse strain, referred herein as Fth Under standard nutritional Fe supply, Fth deletion in adult Fth The FTH component of ferritin acts as a master regulator of organismal Fe homeostasis, coupling nutritional Fe supply to organismal redox homeostasis, energy expenditure and thermoregulation.
Identifiants
pubmed: 30954544
pii: S2212-8778(18)31085-8
doi: 10.1016/j.molmet.2019.03.008
pmc: PMC6531837
pii:
doi:
Substances chimiques
Ferritins
9007-73-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
64-79Subventions
Organisme : Wellcome Trust
ID : 208576/Z/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier GmbH.. All rights reserved.
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