Depressive Symptoms are Associated with Heart Rate Variability Independently of Fitness: A Cross-Sectional Study of Patients with Heart Failure.
Depression
Fitness
Heart failure
Heart rate variability
Journal
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
ISSN: 1532-4796
Titre abrégé: Ann Behav Med
Pays: England
ID NLM: 8510246
Informations de publication
Date de publication:
07 10 2019
07 10 2019
Historique:
pubmed:
9
4
2019
medline:
25
9
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Depression is associated with reduced heart rate variability (HRV) in healthy and cardiac samples, which may be accounted for by physical fitness. In a small sample of cardiac patients, activity and fitness levels attenuated the relationship between HRV and depression. In the current study of heart failure (HF) patients, we hypothesized that depressive symptoms and HRV would be inversely related and physical fitness would attenuate this association. To determine if previous associations among depressive symptoms, physical fitness, and HRV would replicate in a sample of HF patients. The sample consisted of HF patients (N = 125) aged 68.55 ± 8.92 years, 68.8% male, and 83.2% Caucasian. The study was cross-sectional and a secondary analysis of a nonrandomized clinical trial (Trial Identifier: NCT00871897). Depressive symptoms were evaluated using the Beck Depression Inventory (BDI)-II, fitness with the 2 min step test (2MST), and HRV during a 10 min resting laboratory psychophysiology protocol. The dependent variable in hierarchical linear regressions was the root mean square of successive differences. Controlling for sex, age, β-blocker use, hypertension, and diabetes, higher BDI-II scores significantly predicted lower HRV, β = -.29, t(92) = -2.79, p < .01. Adding 2MST did not attenuate the relationship in a follow-up regression. Depressive symptoms were associated with lower HRV in HF patients, independent of physical fitness. Given the prevalence of depression and suppressed HRV common among HF patients, interventions addressing depressive symptoms and other predictors of poor outcomes may be warranted.
Sections du résumé
BACKGROUND
Depression is associated with reduced heart rate variability (HRV) in healthy and cardiac samples, which may be accounted for by physical fitness. In a small sample of cardiac patients, activity and fitness levels attenuated the relationship between HRV and depression. In the current study of heart failure (HF) patients, we hypothesized that depressive symptoms and HRV would be inversely related and physical fitness would attenuate this association.
PURPOSE
To determine if previous associations among depressive symptoms, physical fitness, and HRV would replicate in a sample of HF patients.
METHODS
The sample consisted of HF patients (N = 125) aged 68.55 ± 8.92 years, 68.8% male, and 83.2% Caucasian. The study was cross-sectional and a secondary analysis of a nonrandomized clinical trial (Trial Identifier: NCT00871897). Depressive symptoms were evaluated using the Beck Depression Inventory (BDI)-II, fitness with the 2 min step test (2MST), and HRV during a 10 min resting laboratory psychophysiology protocol. The dependent variable in hierarchical linear regressions was the root mean square of successive differences.
RESULTS
Controlling for sex, age, β-blocker use, hypertension, and diabetes, higher BDI-II scores significantly predicted lower HRV, β = -.29, t(92) = -2.79, p < .01. Adding 2MST did not attenuate the relationship in a follow-up regression.
CONCLUSION
Depressive symptoms were associated with lower HRV in HF patients, independent of physical fitness. Given the prevalence of depression and suppressed HRV common among HF patients, interventions addressing depressive symptoms and other predictors of poor outcomes may be warranted.
Identifiants
pubmed: 30958884
pii: 5432294
doi: 10.1093/abm/kaz006
pmc: PMC6779069
doi:
Banques de données
ClinicalTrials.gov
['NCT00871897']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
955-963Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL096710
Pays : United States
Informations de copyright
© Society of Behavioral Medicine 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Rehabil Med. 2008 Mar;40(3):213-8
pubmed: 18292924
Psychol Med. 2016 Jul;46(10):2121-31
pubmed: 27181276
JAMA. 2008 Nov 26;300(20):2379-88
pubmed: 19033588
J Am Coll Cardiol. 2003 Nov 19;42(10):1811-7
pubmed: 14642693
Biol Psychiatry. 2010 Nov 1;68(9):861-8
pubmed: 20843507
Am Heart J. 2010 Feb;159(2):231-7
pubmed: 20152221
Neuropsychiatr Dis Treat. 2014 Jul 18;10:1335-47
pubmed: 25071372
Am J Epidemiol. 2006 Jan 15;163(2):142-50
pubmed: 16293717
Cleve Clin J Med. 2009 Jan;76(1):59-70
pubmed: 19122112
Cancer. 1984 May 15;53(10 Suppl):2243-9
pubmed: 6704912
Health Psychol. 2012 Nov;31(6):754-62
pubmed: 22924448
Circulation. 2001 Oct 23;104(17):2024-8
pubmed: 11673340
Health Psychol. 2001 Mar;20(2):112-9
pubmed: 11315728
Eur Heart J. 1996 Mar;17(3):354-81
pubmed: 8737210
Percept Mot Skills. 2010 Oct;111(2):608-24
pubmed: 21162459
Eur Heart J. 2000 Mar;21(6):475-82
pubmed: 10681488
Prog Cardiovasc Dis. 2015 Jan-Feb;57(4):306-14
pubmed: 25269064
Hypertens Res. 2011 Jul;34(7):856-61
pubmed: 21562508
Psychophysiology. 1990 Jan;27(1):1-23
pubmed: 2187214
J Am Coll Cardiol. 2005 Nov 15;46(10):1875-82
pubmed: 16286175
Gen Hosp Psychiatry. 2017 Jan - Feb;44:4-9
pubmed: 28041575
Natl Vital Stat Rep. 2015 Aug 31;64(10):1-93
pubmed: 26759854
Psychiatry Res. 2018 Apr;262:482-487
pubmed: 28958456
J Am Coll Cardiol. 1994 Nov 15;24(6):1529-35
pubmed: 7930286
J Psychiatr Res. 2009 Feb;43(5):546-52
pubmed: 18845305
Arch Gen Psychiatry. 1998 Jul;55(7):580-92
pubmed: 9672048
Biol Psychiatry. 2010 Jun 1;67(11):1067-74
pubmed: 20138254
J Am Coll Cardiol. 2006 Oct 17;48(8):1527-37
pubmed: 17045884
PLoS One. 2012;7(2):e30777
pubmed: 22355326
Psychol Med. 2015 Feb;45(3):623-36
pubmed: 25075912
Am J Med. 2007 Sep;120(9):799-806
pubmed: 17765050
Am J Prev Med. 2012 Oct;43(4):361-8
pubmed: 22992353
Biol Psychiatry. 2003 Aug 1;54(3):248-61
pubmed: 12893101
N Engl J Med. 2005 Apr 14;352(15):1539-49
pubmed: 15753115
Am J Epidemiol. 2015 Mar 1;181(5):311-20
pubmed: 25693775
Am J Psychiatry. 2014 Dec 1;171(12):1328-34
pubmed: 25158141
J Am Coll Cardiol. 2009 Nov 3;54(19):1747-62
pubmed: 19874988
Biol Psychol. 2017 Feb;123:94-102
pubmed: 27939700
Int J Environ Res Public Health. 2016 Aug 15;13(8):
pubmed: 27537900
J Psychosom Res. 2000 Apr-May;48(4-5):493-500
pubmed: 10880671
Lancet. 2005 May 28-Jun 3;365(9474):1877-89
pubmed: 15924986
Psychiatry Res. 2017 Oct;256:207-211
pubmed: 28646783
Cardiovasc Res. 1997 Apr;34(1):206-14
pubmed: 9217892
J Am Coll Cardiol. 2008 May 6;51(18):1725-33
pubmed: 18452777
Psychosom Med. 2009 Jun;71(5):519-23
pubmed: 19414614
Arch Intern Med. 2005 Jul 11;165(13):1486-91
pubmed: 16009863
JAMA. 2009 May 20;301(19):2024-35
pubmed: 19454641
J Am Coll Cardiol. 1998 Mar 1;31(3):593-601
pubmed: 9502641