Sleeve Gastrectomy in Obese Zucker Rats Restores Cardiac Function and Geometry Toward a Lean Phenotype Independent of Weight Loss.
Heart failure with preserved ejection fraction
bariatric surgery
diastolic function
obesity
Journal
Journal of cardiac failure
ISSN: 1532-8414
Titre abrégé: J Card Fail
Pays: United States
ID NLM: 9442138
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
27
04
2018
revised:
08
01
2019
accepted:
01
04
2019
pubmed:
9
4
2019
medline:
22
4
2020
entrez:
9
4
2019
Statut:
ppublish
Résumé
Bariatric surgery, including sleeve gastrectomy (SG), significantly improves cardiac geometry and function in patients with heart failure. In this study, we used the obese Zucker rat as an animal model of heart failure with preserved ejection fraction (HFpEF) to test the hypothesis that a SG will improve cardiac function independent of weight loss. Obese, male Zucker rats underwent SG, pair-fed sham, or ad-lib sham surgery. Lean Zucker rats also underwent ad-lib sham surgery. Echocardiograms were performed preoperatively and at 6 weeks postoperatively. Obese SG and obese pair-fed sham rats had similar body weights postoperatively. Obese SG and lean, ad-lib, sham rats had a significant increase in postoperative stroke volume, and left ventricular internal diameter in diastole and systole. SG preserved systolic function and significantly improved isovolumetric relaxation time (13.9 ± 2.4 to 11.1 ± 2.1 ms, P = .02) independent of weight loss. SG has a beneficial impact on both systolic and diastolic cardiac function in obese Zucker rats toward a lean phenotype independent of weight loss and caloric restriction. These findings may represent a weight-loss independent mechanism generated from the gastrointestinal tract that has the potential to improve diastolic dysfunction independent of obesity status and translate to patients with HFpEF.
Identifiants
pubmed: 30959096
pii: S1071-9164(19)30361-6
doi: 10.1016/j.cardfail.2019.04.001
pmc: PMC6596990
mid: NIHMS1528039
pii:
doi:
Substances chimiques
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
372-379Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001438
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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