The Untranslated Regions of mRNAs in Cancer.

3' Untranslated Regions 5' Untranslated Regions Animals Binding Sites Gene Expression Regulation, Neoplastic Genetic Association Studies Genetic Predisposition to Disease Humans Internal Ribosome Entry Sites MicroRNAs / genetics Neoplasms / genetics Polyadenylation Protein Biosynthesis RNA, Messenger / genetics Regulatory Sequences, Ribonucleic Acid Untranslated Regions
3′UTR 5′UTR RNA metabolism cancer mRNA translation somatic mutation therapy untranslated region

Journal

Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956

Informations de publication

Date de publication:
04 2019
Historique:
received: 17 12 2018
revised: 23 02 2019
accepted: 25 02 2019
entrez: 10 4 2019
pubmed: 10 4 2019
medline: 25 6 2020
Statut: ppublish

Résumé

The 5' and 3' untranslated regions (UTRs) regulate crucial aspects of post-transcriptional gene regulation that are necessary for the maintenance of cellular homeostasis. When these processes go awry through mutation or misexpression of certain regulatory elements, the subsequent deregulation of oncogenic gene expression can drive or enhance cancer pathogenesis. Although the number of known cancer-related mutations in UTR regulatory elements has recently increased markedly as a result of advances in whole-genome sequencing, little is known about how the majority of these genetic aberrations contribute functionally to disease. In this review we explore the regulatory functions of UTRs, how they are co-opted in cancer, new technologies to interrogate cancerous UTRs, and potential therapeutic opportunities stemming from these regions.

Identifiants

DOI: 10.1016/j.trecan.2019.02.011 PMID: 30961831 PMC: PMC6465068
pubmed: 30961831
pii: S2405-8033(19)30029-9
doi: 10.1016/j.trecan.2019.02.011
pmc: PMC6465068
mid: NIHMS1523045
pii:
doi:

Substances chimiques

3' Untranslated Regions 0
5' Untranslated Regions 0
Internal Ribosome Entry Sites 0
MicroRNAs 0
RNA, Messenger 0
Regulatory Sequences, Ribonucleic Acid 0
Untranslated Regions 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

245-262

Subventions

Organisme : NCI NIH HHS
ID : K08 CA175154
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA230617
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA230617
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007270
Pays : United States

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

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Auteurs

Samantha L Schuster (SL)

Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

Andrew C Hsieh (AC)

Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA; School of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: ahsieh@fredhutch.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 3' non traduites › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › Régions 5' non traduites › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Études d'associations génétiques › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Séquences régulatrices de l'acide ribonucléique › Sites internes d'entrée des ribosomes › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Tumeurs › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Maturation de l'extrémité 3' des ARN › Polyadénylation › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Biosynthèse des protéines › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Séquences régulatrices de l'acide ribonucléique › The Untranslated Regions of mRNAs in Cancer.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Régions non traduites › The Untranslated Regions of mRNAs in Cancer.