Performance of the COPD Assessment Test in patients with connective tissue disease-associated interstitial lung disease.
Adult
Aged
Blood Gas Analysis
/ methods
Connective Tissue Diseases
/ complications
Cross-Sectional Studies
Dyspnea
/ diagnosis
Exercise
Female
Health Status
Humans
Lung Diseases, Interstitial
/ complications
Male
Middle Aged
Physical Endurance
/ physiology
Pulmonary Disease, Chronic Obstructive
/ blood
Quality of Life
Reproducibility of Results
Respiratory Function Tests
/ methods
Retrospective Studies
Surveys and Questionnaires
/ standards
CAT
COPD Assessment Test
CTD-ILD
Connective tissue disease-associated interstitial lung disease
Health status
Quality of life
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
01
08
2018
revised:
30
11
2018
accepted:
26
01
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
2
5
2020
Statut:
ppublish
Résumé
Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) often experience impaired health status. In daily clinical practice, a short and easy instrument for assessing health status would be useful to help better understand the patient's condition. The COPD Assessment Test (CAT) is a simple questionnaire about respiratory symptoms and their impact. We aimed to examine the CAT's performance characteristics and to generate data to support its reliability and validity in patients with CTD-ILD. We used data from 132 CTD-ILD patients evaluated at Tosei General Hospital from July 2011 to July 2016 to assess the cross-sectional and longitudinal validity of the CAT. The mean age of the patients was 64.5 years and 87 (66%) were women. There were no significant differences in CAT score between any of the CTD subgroups. Internal consistency (Cronbach's α = 0.881) and repeatability (intraclass correlation coefficient [ICC] = 0.803) for the CAT score were acceptable. At baseline, CAT score was significantly associated with clinically meaningful measures of physiologic function, exercise capacity, and dyspnea. Change in CAT score over 6-12 months was also associated with change in other measures. In the distribution- and anchor-based analyses, the estimated minimal clinically important difference of CAT score was 1-4 points. These data support the validity and reliability of CAT as a sensitive measure for assessing health status in patients with CTD-ILD.
Sections du résumé
BACKGROUND
Patients with connective tissue disease-associated interstitial lung disease (CTD-ILD) often experience impaired health status. In daily clinical practice, a short and easy instrument for assessing health status would be useful to help better understand the patient's condition. The COPD Assessment Test (CAT) is a simple questionnaire about respiratory symptoms and their impact. We aimed to examine the CAT's performance characteristics and to generate data to support its reliability and validity in patients with CTD-ILD.
METHODS
We used data from 132 CTD-ILD patients evaluated at Tosei General Hospital from July 2011 to July 2016 to assess the cross-sectional and longitudinal validity of the CAT.
RESULTS
The mean age of the patients was 64.5 years and 87 (66%) were women. There were no significant differences in CAT score between any of the CTD subgroups. Internal consistency (Cronbach's α = 0.881) and repeatability (intraclass correlation coefficient [ICC] = 0.803) for the CAT score were acceptable. At baseline, CAT score was significantly associated with clinically meaningful measures of physiologic function, exercise capacity, and dyspnea. Change in CAT score over 6-12 months was also associated with change in other measures. In the distribution- and anchor-based analyses, the estimated minimal clinically important difference of CAT score was 1-4 points.
CONCLUSION
These data support the validity and reliability of CAT as a sensitive measure for assessing health status in patients with CTD-ILD.
Identifiants
pubmed: 30961943
pii: S0954-6111(19)30033-2
doi: 10.1016/j.rmed.2019.01.017
pii:
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-20Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.