B-cell dynamics during experimental endotoxemia in humans.
B-cells
BAFF
Endotoxemia
LPS
inflammation
sepsis
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
31 05 2019
31 05 2019
Historique:
received:
31
07
2018
revised:
28
03
2019
accepted:
05
04
2019
pubmed:
10
4
2019
medline:
11
6
2020
entrez:
10
4
2019
Statut:
epublish
Résumé
Recently, B cells with regulatory functions suppressing T-cell immunity were identified. Inflammation in the context of sepsis is characterized by a profound immune dysfunction increasing the patient's risk for additional infections. The impact of endotoxemia on B-cell dynamics, regulatory B cells (Breg) and its contribution to immune dysfunction is unknown. It is the aim of the present study to characterize the dynamics of the B-cell compartment and Breg in an experimental human endotoxemia model.In this randomized placebo-controlled cross-over study, 20 healthy males received an intravenous injection of endotoxin (
Identifiants
pubmed: 30962268
pii: BSR20182347
doi: 10.1042/BSR20182347
pmc: PMC6522728
pii:
doi:
Substances chimiques
Cytokines
0
Endotoxins
0
Lipopolysaccharides
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2019 The Author(s).
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