Synthesis of saporin-antibody conjugates for targeting EpCAM positive tumour cells.
Journal
IET nanobiotechnology
ISSN: 1751-875X
Titre abrégé: IET Nanobiotechnol
Pays: United States
ID NLM: 101303205
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
27
8
2019
Statut:
ppublish
Résumé
Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein involved in cell proliferation and differentiation. Ribosomal inactivating proteins derived from plants specifically target ribosomes and irreversibly inhibit protein synthesis. EpCAM antibody and saporin were conjugated using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride/
Identifiants
pubmed: 30964044
doi: 10.1049/iet-nbt.2018.5222
pmc: PMC8676438
doi:
Substances chimiques
Antibodies
0
Antineoplastic Agents
0
Epithelial Cell Adhesion Molecule
0
Saporins
EC 3.2.2.22
Types de publication
Journal Article
Langues
eng
Pagination
90-99Références
Biochim Biophys Acta. 2012 Jan;1825(1):18-28
pubmed: 21982838
Cell. 2003 Jun 13;113(6):717-30
pubmed: 12809603
J Control Release. 2012 Jul 20;161(2):175-87
pubmed: 21945285
Dig Dis Sci. 2010 Aug;55(8):2165-71
pubmed: 19941073
Am J Pathol. 2007 Aug;171(2):386-95
pubmed: 17600130
Oncogene. 2004 Dec 16;23(58):9336-47
pubmed: 15531928
Exp Mol Med. 2008 Jun 30;40(3):345-53
pubmed: 18587273
Biochim Biophys Acta. 2013 Aug;1828(8):1989-2001
pubmed: 23618806
Anticancer Res. 2017 Jul;37(7):3615-3629
pubmed: 28668853
Adv Drug Deliv Rev. 2014 Feb;66:2-25
pubmed: 24270007
Breast Cancer Res. 2005;7(2):R238-47
pubmed: 15743504
Biochim Biophys Acta. 2005 Jul 15;1735(2):135-50
pubmed: 15979399
Annu Rev Plant Physiol Plant Mol Biol. 2001 Jun;52:785-816
pubmed: 11337416
Mol Cell Biol. 2003 May;23(10):3477-86
pubmed: 12724406
MAbs. 2014 Jan-Feb;6(1):34-45
pubmed: 24423619
MAbs. 2014 Jul-Aug;6(4):1038-50
pubmed: 24525727
BMC Cancer. 2011 Jan 31;11:45
pubmed: 21281469
Toxins (Basel). 2013 Oct 07;5(10):1698-722
pubmed: 24105401
Biochem Biophys Res Commun. 2016 Jan 8;469(2):257-62
pubmed: 26642954
Clin Cancer Res. 2011 Oct 15;17(20):6389-97
pubmed: 22003066
J Cell Biol. 2002 Jun 24;157(7):1175-86
pubmed: 12082078
Breast Cancer Res Treat. 2010 Oct;123(3):701-8
pubmed: 20012351
Curr Med Chem. 2008;15(5):422-32
pubmed: 18288997
Drug Discov Today. 2012 Jul;17(13-14):774-83
pubmed: 22484096
Mol Biol Rep. 2001;28(4):185-91
pubmed: 12153137
Anticancer Res. 1998 Sep-Oct;18(5B):3669-75
pubmed: 9854475
Nat Cell Biol. 2009 Feb;11(2):162-71
pubmed: 19136966
Toxicol In Vitro. 2013 Feb;27(1):220-31
pubmed: 23085102
FEBS Lett. 2005 Feb 28;579(6):1324-31
pubmed: 15733836