High intensity interval training promotes total and visceral fat mass loss in obese Zucker rats without modulating gut microbiota.
Acute-Phase Proteins
Animals
Body Composition
Carrier Proteins
/ blood
Energy Metabolism
Gastrointestinal Microbiome
Gene Expression Regulation
Glucose
/ metabolism
Intra-Abdominal Fat
/ metabolism
Male
Membrane Glycoproteins
/ blood
Occludin
/ genetics
Physical Conditioning, Animal
Rats
Rats, Zucker
Receptors, Adrenergic, alpha
/ metabolism
Receptors, Adrenergic, beta
/ metabolism
Zonula Occludens-1 Protein
/ genetics
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
12
2018
accepted:
19
03
2019
entrez:
10
4
2019
pubmed:
10
4
2019
medline:
24
12
2019
Statut:
epublish
Résumé
Increased visceral adipose tissue and dysbiosis in the overweight and obese promote chronic inflammation. The aim of this study was to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on the gut-adipose tissue cross-talk in obese Zucker rats. Obese male Zucker rats (n = 36) were divided in three groups: MICT (12m.min-1 for 51min), HIIT (6 sets at 18 m.min-1 for 4min followed by 3min at 10m.min-1) and controls (CONT; no exercise). The animals ran on a treadmill 5 days/week for 10 weeks. Body composition, glycaemic control, lipid profile, inflammation, lipolysis signalling in subcutaneous and visceral adipose tissue, intestinal permeability (tight junctions and plasma lipopolysaccharide binding protein; LBP), and gut microbiota composition were assessed in the three groups. After 10 weeks of exercise, total and epididymal fat mass decreased only in the HIIT group. The α/β adrenergic receptor RNA ratio in subcutaneous adipose tissue increased only in the HIIT group. The expression level of phosphorylated hormone-sensitive lipase was not modified by training. Both HIIT and MICT decreased inflammation (plasma myeloperoxidase and keratinocyte-derived chemokine secretion in adipose tissue) and improved glucose metabolism. Zonula occludens-1 and occludin were upregulated in the HIIT group. Plasma LBP was similarly reduced in both training groups. HIIT and MICT did not affect gut microbiota composition. In obese Zucker rats, HIIT and MICT improved inflammation and glucose metabolism. In contrast, only HIIT decreased total and visceral fat mass. These adaptations were not associated with modifications in gut microbiota composition.
Identifiants
pubmed: 30964881
doi: 10.1371/journal.pone.0214660
pii: PONE-D-18-34409
pmc: PMC6456220
doi:
Substances chimiques
Acute-Phase Proteins
0
Carrier Proteins
0
Membrane Glycoproteins
0
Occludin
0
Receptors, Adrenergic, alpha
0
Receptors, Adrenergic, beta
0
Zonula Occludens-1 Protein
0
lipopolysaccharide-binding protein
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0214660Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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