Low-Dose Anti-Thymocyte Globulin Preserves C-Peptide, Reduces HbA
Adolescent
Adult
Antilymphocyte Serum
/ therapeutic use
C-Peptide
/ metabolism
CD4-CD8 Ratio
Child
Diabetes Mellitus, Type 1
/ drug therapy
Double-Blind Method
Female
Flow Cytometry
Glycated Hemoglobin
/ metabolism
Granulocyte Colony-Stimulating Factor
/ therapeutic use
Humans
Immunologic Factors
/ therapeutic use
Male
T-Lymphocytes, Regulatory
/ immunology
Young Adult
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
17
01
2019
accepted:
23
03
2019
pubmed:
11
4
2019
medline:
24
12
2019
entrez:
11
4
2019
Statut:
ppublish
Résumé
A three-arm, randomized, double-masked, placebo-controlled phase 2b trial performed by the Type 1 Diabetes TrialNet Study Group previously demonstrated that low-dose anti-thymocyte globulin (ATG) (2.5 mg/kg) preserved β-cell function and reduced HbA
Identifiants
pubmed: 30967424
pii: db19-0057
doi: 10.2337/db19-0057
pmc: PMC6610026
doi:
Substances chimiques
Antilymphocyte Serum
0
C-Peptide
0
Glycated Hemoglobin A
0
Immunologic Factors
0
hemoglobin A1c protein, human
0
Granulocyte Colony-Stimulating Factor
143011-72-7
Banques de données
ClinicalTrials.gov
['NCT02215200']
Types de publication
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1267-1276Subventions
Organisme : NIDDK NIH HHS
ID : U01 DK085476
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061010
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001857
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103266
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK106993
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK107014
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001085
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061042
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085509
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK117009
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI042288
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI109565
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085466
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001872
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103153
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061058
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002529
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK106984
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000114
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085499
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001427
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103282
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061034
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001082
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085461
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK097835
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085465
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003142
Pays : United States
Investigateurs
Carla J Greenbaum
(CJ)
Mark A Atkinson
(MA)
David A Baidal
(DA)
Manuela Battaglia
(M)
Dorothy Becker
(D)
Penelope Bingley
(P)
Emanuele Bosi
(E)
Jane Buckner
(J)
Mark Clements
(M)
Peter G Colman
(PG)
Linda DiMeglio
(L)
Carmella Evans-Molina
(C)
Stephen E Gitelman
(SE)
Robin Goland
(R)
Peter Gottlieb
(P)
Kevan Herold
(K)
Mikael Knip
(M)
Jeffrey P Krischer
(JP)
Ake Lernmark
(A)
Wayne Moore
(W)
Antoinette Moran
(A)
Andrew Muir
(A)
Jerry Palmer
(J)
Mark Peakman
(M)
Louis Philipson
(L)
Philip Raskin
(P)
Maria Redondo
(M)
Henry Rodriguez
(H)
William Russell
(W)
Desmond A Schatz
(DA)
Jay M Sosenko
(JM)
Lisa Spain
(L)
John Wentworth
(J)
Diane Wherrett
(D)
Darrell M Wilson
(DM)
William Winter
(W)
Anette Ziegler
(A)
Mark Anderson
(M)
Peter Antinozzi
(P)
Richard Insel
(R)
Thomas Kay
(T)
Jennifer B Marks
(JB)
Alberto Pugliese
(A)
Bart Roep
(B)
Jay S Skyler
(JS)
Jorma Toppari
(J)
Carla J Greenbaum
(CJ)
Jeffrey P Krischer
(JP)
Ellen Leschek
(E)
Lisa Spain
(L)
Katarzyna Bourcier
(K)
Richard Insel
(R)
John Ridge
(J)
Jay S Skyler
(JS)
Carla J Greenbaum
(CJ)
Lisa Rafkin
(L)
Jay M Sosenko
(JM)
Jay S Skyler
(JS)
Irene Santiago
(I)
Jeffrey P Krischer
(JP)
Brian Bundy
(B)
Michael Abbondondolo
(M)
Timothy Adams
(T)
Ilma Asif
(I)
Jenna Bjellquist
(J)
Matthew Boonstra
(M)
Cristina Burroughs
(C)
Mario Cleves
(M)
David Cuthbertson
(D)
Meagan DeSalvatore
(M)
Christopher Eberhard
(C)
Steve Fiske
(S)
Julie Ford
(J)
Jennifer Garmeson
(J)
Susan Geyer
(S)
Brian Hays
(B)
Courtney Henderson
(C)
Martha Henry
(M)
Kathleen Heyman
(K)
Belinda Hsiao
(B)
Christina Karges
(C)
Beata-Gabriela Koziol
(BG)
Lindsay Lane
(L)
Shu Liu
(S)
Jennifer Lloyd
(J)
Kristin Maddox
(K)
Jamie Malloy
(J)
Julie Martin
(J)
Cameron McNeill
(C)
Margaret Moore
(M)
Sarah Muller
(S)
Thuy Nguyen
(T)
Jodie Nunez
(J)
Ryan O'Donnell
(R)
Melissa Parker
(M)
M J Pereyra
(MJ)
Amy Roberts
(A)
Kelly Sadler
(K)
Christine Sullivan
(C)
Roy Tamura
(R)
Elon Walker-Veras
(E)
Megan V Warnock
(MV)
Keith Wood
(K)
Rebecca Wood
(R)
Ping Xu
(P)
Vanessa Yanek
(V)
Kenneth Young
(K)
Darlene Amado
(D)
Amanda Kinderman
(A)
Ashley Leinbach
(A)
Jessica Miller
(J)
Nichole Reed
(N)
Tina Stavros
(T)
Ellen Leschek
(E)
Lisa Spain
(L)
Emily Blumberg
(E)
Sean Aas
(S)
Gerald Beck
(G)
Rose Gubitosi-Klug
(R)
Lori Laffel
(L)
Robert Vigersky
(R)
Dennis Wallace
(D)
David Brillon
(D)
Robert Veatch
(R)
Brett Loechelt
(B)
Lindsey Baden
(L)
Peter Gottlieb
(P)
Michael Green
(M)
Ellen Leschek
(E)
Adriana Weinberg
(A)
Santica Marcovina
(S)
Jerry P Palmer
(JP)
Jay Tischfield
(J)
Adriana Weinberg
(A)
William Winter
(W)
Liping Yu
(L)
Annie Shultz
(A)
Emily Batts
(E)
Arielle Pagryzinski
(A)
Mary Ramey
(M)
Meghan Tobin
(M)
Kristin Fitzpatrick
(K)
Randy Guerra
(R)
Melita Romasco
(M)
Christopher Webb
(C)
Peter Gottlieb
(P)
Maya Barr
(M)
Mary Drye
(M)
Jordan Lykens
(J)
Aaron Michels
(A)
Allison Schauwecker
(A)
Andrea Steck
(A)
Paul Wadwa
(P)
Carla J Greenbaum
(CJ)
Jane Buckner
(J)
Wei Hao
(W)
Sandra Lord
(S)
Marli McCulloch-Olson
(M)
Mary Ramey
(M)
Elaine Sachter
(E)
Jenna Snavely
(J)
Meghan Tobin
(M)
Corinna Tordillos
(C)
Dana VanBuecken
(D)
Robin Goland
(R)
Analia Alvarez
(A)
Magdalena Bogun
(M)
Rachelle Gandica
(R)
Natasha Leibel
(N)
Sarah Pollak
(S)
Barney Softness
(B)
Kristen Williams
(K)
Bryce Nelson
(B)
James Amrhein
(J)
Lisa Looper
(L)
Elaine Moreland
(E)
Andrew Smith
(A)
Beth Weir
(B)
Lori Wise
(L)
Linda DiMeglio
(L)
Carmella Evans-Molina
(C)
Manasa Mantravadi
(M)
Maureen Mullen
(M)
Vanessa Patrick
(V)
Maria Spall
(M)
Stephanie Woerner
(S)
Darrell M Wilson
(DM)
Nora Arrizon-Ruiz
(N)
Tandy Aye
(T)
Laura Bachrach
(L)
Karen Barahona
(K)
Trudy Esrey
(T)
Laura Nally
(L)
Stephen E Gitelman
(SE)
Mark Anderson
(M)
Glenna Auerback
(G)
Jeanne Buchanan
(J)
Christine T Ferrara
(CT)
Karen Ko
(K)
Srinath Sanda
(S)
Christine Torok
(C)
Rebecca Wesch
(R)
Michael J Haller
(MJ)
Anastasia Albanese-O'Neill
(A)
Todd Brusko
(T)
Miriam Cintron
(M)
Jennifer Hosford
(J)
Laura M Jacobsen
(LM)
Henry Rohrs
(H)
Desmond A Schatz
(DA)
Janet Silverstein
(J)
Paula Towe
(P)
David A Baidal
(DA)
Carlos Blaschke
(C)
Della Matheson
(D)
Janine Sanchez
(J)
Natalia Sanders-Branca
(N)
Jay S Skyler
(JS)
Jay M Sosenko
(JM)
Antoinette Moran
(A)
Janice Leschyshyn
(J)
Jennifer McVean
(J)
Brandon Nathan
(B)
Brittney Nelson
(B)
Beth Pappenfus
(B)
Jessica Ruedy
(J)
Anne Street
(A)
Muna Sunni
(M)
Darcy Weingartner
(D)
Dorothy Becker
(D)
Kelli DeLallo
(K)
Ana Diaz
(A)
David Groscost
(D)
Mary Beth Klein
(M)
Ingrid Libman
(I)
Karen Riley
(K)
Henry Rodriguez
(H)
Sureka Bollepalli
(S)
Rachel Brownstein
(R)
Emily Eyth
(E)
Danielle Henson
(D)
Michele Laine
(M)
Dorothy Shulman
(D)
William Russell
(W)
Faith Brendle
(F)
Anne Brown
(A)
Brenna Dixon
(B)
Justin Gregory
(J)
Dan Moore
(D)
James Thomas
(J)
Kevan Herold
(K)
Laurie Feldman
(L)
William Tamborlane
(W)
Informations de copyright
© 2019 by the American Diabetes Association.
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