Selective biocatalytic hydroxylation of unactivated methylene C-H bonds in cyclic alkyl substrates.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
23 Apr 2019
23 Apr 2019
Historique:
pubmed:
11
4
2019
medline:
8
5
2019
entrez:
11
4
2019
Statut:
ppublish
Résumé
The cytochrome P450 monooxygenase CYP101B1 from Novosphingobium aromaticivorans selectively hydroxylated methylene C-H bonds in cycloalkyl rings. Cycloketones and cycloalkyl esters containing C6, C8, C10 and C12 rings were oxidised with high selectively on the opposite side of the ring to the carbonyl substituent. Cyclodecanone was oxidised to oxabicycloundecanol derivatives in equilibrium with the hydroxycyclodecanones.
Substances chimiques
Cycloparaffins
0
carbene
2465-56-7
Cytochrome P-450 Enzyme System
9035-51-2
Methane
OP0UW79H66
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM