Anti-CD133 Monoclonal Antibody CMab-43 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer.

AC133 Antigen / immunology Animals Antibodies, Monoclonal / administration & dosage Colonic Neoplasms / drug therapy Female Humans Mice Mice, Inbred BALB C Mice, Nude Tumor Cells, Cultured Xenograft Model Antitumor Assays
CD133 Caco-2 colon cancers monoclonal antibody

Journal

Monoclonal antibodies in immunodiagnosis and immunotherapy
ISSN: 2167-9436
Titre abrégé: Monoclon Antib Immunodiagn Immunother
Pays: United States
ID NLM: 101590955

Informations de publication

Date de publication:
Apr 2019
Historique:
pubmed: 11 4 2019
medline: 14 8 2019
entrez: 11 4 2019
Statut: ppublish

Résumé

Cancer stem cells contribute to tumorigenesis, metastasis, recurrence, and chemoresistance. CD133/prominin-1-a pentaspan membrane glycoprotein-has been used as a stem cell biomarker for the isolation of stem-like cells from a variety of normal and pathological tissues. In our previous studies, we developed several anti-CD133 monoclonal antibodies using Cell-Based Immunization and Screening (CBIS) methods, followed by characterization of their efficacy by flow cytometry, western blotting, and immunohistochemical analyses. One of the 100 clones, CMab-43 (IgG

Identifiants

DOI: 10.1089/mab.2019.0002 PMID: 30969150
pubmed: 30969150
doi: 10.1089/mab.2019.0002
doi:

Substances chimiques

AC133 Antigen 0
Antibodies, Monoclonal 0
PROM1 protein, human 0

Types de publication

Journal Article

Langues

eng

Pagination

75-78

Auteurs

Yukinari Kato (Y)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
2 New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.

Tomokazu Ohishi (T)

3 Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan.

Shinji Yamada (S)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Shunsuke Itai (S)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Yoshikazu Furusawa (Y)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.
2 New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.

Masato Sano (M)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Takuro Nakamura (T)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

Manabu Kawada (M)

3 Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Numazu-shi, Japan.

Mika K Kaneko (MK)

1 Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, Sendai, Japan.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Antigène AC133 › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Eucaryotes › Animaux › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Tumeurs de l'intestin › Tumeurs du côlon › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris nude › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...
questionsmedicales.fr › Techniques d'investigation › Transplantation tumorale › Tests d'activité antitumorale sur modèle de xénogreffe › Anti-CD133 Monoclonal Antibody CMab-43 Exerts...