Binding and transport of D-aspartate by the glutamate transporter homolog Glt
Thermococcus kodakarensis
X-ray crystallography
enantiomer
excitatory amino acid transporters
glutamate transporters
membrane transport
molecular biophysics
structural biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 04 2019
10 04 2019
Historique:
received:
17
01
2019
accepted:
09
04
2019
pubmed:
11
4
2019
medline:
12
3
2020
entrez:
11
4
2019
Statut:
epublish
Résumé
Mammalian glutamate transporters are crucial players in neuronal communication as they perform neurotransmitter reuptake from the synaptic cleft. Besides L-glutamate and L-aspartate, they also recognize D-aspartate, which might participate in mammalian neurotransmission and/or neuromodulation. Much of the mechanistic insight in glutamate transport comes from studies of the archeal homologs Glt
Identifiants
pubmed: 30969168
doi: 10.7554/eLife.45286
pii: 45286
pmc: PMC6482001
doi:
pii:
Substances chimiques
Amino Acid Transport System X-AG
0
D-Aspartic Acid
4SR0Q8YD1X
Sodium
9NEZ333N27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 282083
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 723014.002
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 865.11.001
Pays : International
Organisme : Nederlandse Organisatie voor Wetenschappelijk Onderzoek
ID : 723.014.002
Pays : International
Informations de copyright
© 2019, Arkhipova et al.
Déclaration de conflit d'intérêts
VA, GT, TE, SJ, DS, AG No competing interests declared
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