Autophagy Regulation of Metabolism Is Required for CD8

Animals Autophagy CD8-Positive T-Lymphocytes / immunology Humans Mice Neoplasms / immunology
CD8(+) T cells SAM anti-tumor immunity autophagy glycolysis lactate methylation

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
09 04 2019
Historique:
received: 06 03 2018
revised: 14 02 2019
accepted: 08 03 2019
entrez: 11 4 2019
pubmed: 11 4 2019
medline: 23 6 2020
Statut: ppublish

Résumé

Autophagy is a cell survival process essential for the regulation of immune responses to infections. However, the role of T cell autophagy in anti-tumor immunity is less clear. Here, we demonstrate a cell-autonomous role for autophagy in the regulation of CD8

Identifiants

DOI: 10.1016/j.celrep.2019.03.037 PMID: 30970253
pubmed: 30970253
pii: S2211-1247(19)30353-5
doi: 10.1016/j.celrep.2019.03.037
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

502-513.e5

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States

Informations de copyright

Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.

Auteurs

Lindsay DeVorkin (L)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.

Nils Pavey (N)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.

Gillian Carleton (G)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

Alexandra Comber (A)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada.

Cally Ho (C)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

Junghyun Lim (J)

Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA.

Erin McNamara (E)

Department of In Vivo Pharmacology, Genentech, Inc., South San Francisco, CA, USA.

Haochu Huang (H)

Department of In Vivo Pharmacology, Genentech, Inc., South San Francisco, CA, USA.

Paul Kim (P)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada.

Lauren G Zacharias (LG)

Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Noboru Mizushima (N)

Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Tatsuya Saitoh (T)

Division of Inflammation Biology, Institute for Enzyme Research, Tokushima University, Tokushima, Japan.

Shizuo Akira (S)

Department of Host Defense, World Premier International Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.

Wayne Beckham (W)

BC Cancer-Vancouver Island Centre, Medical Physics, Victoria, BC, Canada; Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada.

Alireza Lorzadeh (A)

Department of Microbiology and Immunology and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

Michelle Moksa (M)

Department of Microbiology and Immunology and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

Qi Cao (Q)

Department of Microbiology and Immunology and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada.

Aditya Murthy (A)

Department of Cancer Immunology, Genentech, Inc., South San Francisco, CA, USA.

Martin Hirst (M)

Department of Microbiology and Immunology and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada; Canada's Michael Smith Genome Science Center, BC Cancer, Vancouver, BC, Canada.

Ralph J DeBerardinis (RJ)

Children's Medical Center Research Institute, Department of Pediatrics and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Julian J Lum (JJ)

Trev and Joyce Deeley Research Centre, BC Cancer, Victoria, BC, Canada; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada. Electronic address: jjlum@bccancer.bc.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Autophagy Regulation of Metabolism Is Required for CD8
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Autophagy Regulation of Metabolism Is Required for CD8
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Autophagy Regulation of Metabolism Is Required for CD8
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Autophagy Regulation of Metabolism Is Required for CD8
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Autophagy Regulation of Metabolism Is Required for CD8
questionsmedicales.fr › Tumeurs › Autophagy Regulation of Metabolism Is Required for CD8