HIV serostatus, viral load, and midtrimester cervical length in a Zambian prenatal cohort.
HIV
Cervical length
Preterm birth
Sub-Saharan Africa
Viral load
Zambia
Journal
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
ISSN: 1879-3479
Titre abrégé: Int J Gynaecol Obstet
Pays: United States
ID NLM: 0210174
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
15
05
2018
revised:
12
11
2018
accepted:
10
04
2019
pubmed:
12
4
2019
medline:
4
9
2019
entrez:
12
4
2019
Statut:
ppublish
Résumé
To evaluate whether maternal HIV serostatus and plasma viral load (VL) are associated with midtrimester cervical length (CL). The Zambian Preterm Birth Prevention Study (ZAPPS) is an ongoing prospective cohort that began enrolling in Lusaka in August 2015. Pregnant women undergo ultrasound to determine gestational age and return for CL measurement at 16-28 weeks. We evaluated crude and adjusted associations between dichotomous indicators and short cervix (≤2.5 cm) via logistic regression, and between VL and CL as a continuous variable via linear regression. This analysis includes 1171 women enrolled between August 2015 and September 2017. Of 294 (25.1%) HIV-positive women, 275 (93.5%) had viral load performed close to CL measurement; of these, 148 (53.8%) had undetectable virus. Median CL was 3.6 cm (IQR 3.5-4.0) and was similar in HIV-infected (3.7 cm, IQR 3.5-4.0) versus uninfected (3.6 cm, IQR 3.5-4.0) participants (P=0.273). The odds of short CL were similar by HIV serostatus (OR 0.64; P=0.298) and detectable VL among those infected (OR 2.37, P=0.323). We observed no association between log VL and CL via linear regression (-0.12 cm; P=0.732). We found no evidence of association between HIV infection and short CL.
Identifiants
pubmed: 30973655
doi: 10.1002/ijgo.12823
pmc: PMC6610732
mid: NIHMS1023668
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-211Subventions
Organisme : FIC NIH HHS
ID : D43 TW010558
Pays : United States
Organisme : NIAID NIH HHS
ID : K24 AI120796
Pays : United States
Organisme : NIH HHS
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW009340
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States
Organisme : FIC NIH HHS
ID : K01 TW010857
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD075731
Pays : United States
Informations de copyright
© 2019 International Federation of Gynecology and Obstetrics.
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