Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant


Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
10 04 2019
Historique:
received: 13 03 2019
revised: 28 03 2019
accepted: 04 04 2019
entrez: 13 4 2019
pubmed: 13 4 2019
medline: 18 1 2020
Statut: epublish

Résumé

Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment. We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition of this biofilm by AMPs to be used as treatment or coating. Antimicrobial activity and antibiofilm were tested with wasp (Agelaia-MPI, Polybia-MPII, Polydim-I) and scorpion (Con10 and NDBP5.8) AMPs against

Identifiants

pubmed: 30974767
pii: toxins11040216
doi: 10.3390/toxins11040216
pmc: PMC6520840
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Antimicrobial Cationic Peptides 0
Chromium Alloys 0
Scorpion Venoms 0
Wasp Venoms 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

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Auteurs

Rogério Coutinho das Neves (RC)

Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Goiania, 74605-050 Goiás, Brazil. rogeriocdasneves@hotmail.com.

Márcia Renata Mortari (MR)

Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, 70910-900 Brasilia, Brazil. mamortari@gmail.com.

Elisabeth Ferroni Schwartz (EF)

Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, 70910-900 Brasilia, Brazil. beth.ferroni@gmail.com.

André Kipnis (A)

Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Goiania, 74605-050 Goiás, Brazil. andre.kipnis@gmail.com.

Ana Paula Junqueira-Kipnis (AP)

Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Goiania, 74605-050 Goiás, Brazil. ana_kipnis@ufg.br.

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Classifications MeSH