Functional capillary impairment in patients with ventricular assist devices.
Aged
Capillaries
/ pathology
Cardiomyopathies
/ pathology
Case-Control Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Heart Failure
/ pathology
Heart-Assist Devices
/ adverse effects
Humans
Male
Microcirculation
Microvascular Rarefaction
/ etiology
Middle Aged
Myocardial Ischemia
/ pathology
Prognosis
Retrospective Studies
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
received:
22
08
2018
accepted:
29
03
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
2
10
2020
Statut:
epublish
Résumé
The implantation of continuous - flow ventricular assist devices (VAD) is suggested to evoke angiodysplasia contributing to adverse events such as gastrointestinal bleeding. We evaluated in vivo capillary density and glycocalyx dimensions to investigate possible systemic microvascular changes in patients with chronic heart failure and VAD support vs. standard medical treatment. Forty-two patients with VAD support were compared to forty-one patients with ischemic and non-ischemic chronic heart failure (CHF) on standard pharmacotherapy and to a group of forty-two healthy subjects in a prospective cross-sectional study. Sublingual microcirculation was visualized using Sidestream Darkfield videomicroscopy and functional and perfused total capillary densities were quantified. Patients with VAD implantation were followed for one year and bleeding events were recorded. Median time after VAD implantation was 18 months. Patients were treated with centrifugal-flow devices (n = 31) or axial-flow devices (n = 11). Median functional capillary density was significantly lower in patients with VAD therapy as compared to CHF patients (196 vs. 255/mm
Identifiants
pubmed: 30976042
doi: 10.1038/s41598-019-42334-3
pii: 10.1038/s41598-019-42334-3
pmc: PMC6459831
doi:
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5909Références
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