Usefulness of serum microRNA as a predictive marker of recurrence and prognosis in biliary tract cancer after radical surgery.
Adult
Aged
Aged, 80 and over
Biliary Tract Neoplasms
/ pathology
Biliary Tract Surgical Procedures
/ mortality
Biomarkers, Tumor
/ blood
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Humans
Incidence
Japan
/ epidemiology
Male
MicroRNAs
/ blood
Middle Aged
Neoplasm Recurrence, Local
/ blood
Prognosis
Survival Rate
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
received:
25
10
2018
accepted:
20
03
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Biliary tract cancer (BTC) is an aggressive type of malignant tumour. Even after radical resection, the risk of recurrence is still high, resulting in a poor prognosis. Here, we investigated the usefulness of serum miRNAs as predictive markers of recurrence and prognosis for patients with BTC after radical surgery using 66 serum samples that were collected at three time points from 22 patients with BTC who underwent radical surgery. Using microarray analysis, we successfully identified six specific miRNAs (miR-1225-3p, miR-1234-3p, miR1260b, miR-1470, miR-6834-3p, and miR-6875-5p) associated with recurrence and prognosis of BTC after radical surgery. In addition, using a combination of these miRNAs, we developed a recurrence predictive index to predict recurrence in patients with BTC after operation with high accuracy. Patients having higher index scores (≥ cut-off) had significantly worse recurrence-free survival (RFS) and overall survival (OS) than those with lower index scores (<cut-off). Furthermore, the index was an independent factor related to RFS and OS by univariate and multivariate analyses using a Cox hazard proportional model. Overall, our results provided compelling evidence for the potential usefulness of specific serum miRNAs as effective predictive tools for recurrence and prognosis in patients with BTC who underwent radical surgery.
Identifiants
pubmed: 30976046
doi: 10.1038/s41598-019-42392-7
pii: 10.1038/s41598-019-42392-7
pmc: PMC6459925
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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