Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXa
Animals
Blood Coagulation
/ drug effects
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical
/ methods
Factor Xa
/ administration & dosage
Female
Half-Life
Hemophilia A
/ blood
Humans
Macaca fascicularis
Male
Mice
Partial Thromboplastin Time
Prothrombin Time
Rats
Recombinant Proteins
/ administration & dosage
Sequence Homology, Amino Acid
Species Specificity
FXaI16L
anti-drug antibody
coagulation factor
exposure day
hemophilia inhibitor
neutralizing antibody
Journal
The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209
Informations de publication
Date de publication:
11 04 2019
11 04 2019
Historique:
received:
02
01
2019
accepted:
22
03
2019
entrez:
13
4
2019
pubmed:
13
4
2019
medline:
3
3
2020
Statut:
epublish
Résumé
This paper presents a systemic investigation of ADA development and ADA impact of a human coagulation factor in nonclinical species during drug development and provides insights into potential implications in human if a similar ADA occurs. FXa
Identifiants
pubmed: 30976993
doi: 10.1208/s12248-019-0324-z
pii: 10.1208/s12248-019-0324-z
doi:
Substances chimiques
Recombinant Proteins
0
Factor Xa
EC 3.4.21.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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