Environmental heterogeneity can tip the population genetics of range expansions.
E. coli
environmental heterogeneity
evolutionary biology
evolutionary dynamics
microbial ecology
physics of living systems
range expansions
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 04 2019
12 04 2019
Historique:
received:
18
12
2018
accepted:
11
04
2019
pubmed:
13
4
2019
medline:
12
3
2020
entrez:
13
4
2019
Statut:
epublish
Résumé
The population genetics of most range expansions is thought to be shaped by the competition between Darwinian selection and random genetic drift at the range margins. Here, we show that the evolutionary dynamics during range expansions is highly sensitive to additional fluctuations induced by environmental heterogeneities. Tracking mutant clones with a tunable fitness effect in bacterial colonies grown on randomly patterned surfaces we found that environmental heterogeneity can dramatically reduce the efficacy of selection. Time-lapse microscopy and computer simulations suggest that this effect arises generically from a local 'pinning' of the expansion front, whereby stretches of the front are slowed down on a length scale that depends on the structure of the environmental heterogeneity. This pinning focuses the range expansion into a small number of 'lucky' individuals with access to expansion paths, altering the neutral evolutionary dynamics and increasing the importance of chance relative to selection.
Identifiants
pubmed: 30977724
doi: 10.7554/eLife.44359
pii: 44359
pmc: PMC6513619
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM115851
Pays : United States
Informations de copyright
© 2019, Gralka and Hallatschek.
Déclaration de conflit d'intérêts
MG, OH No competing interests declared
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