Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra.
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Line, Tumor
Drug Screening Assays, Antitumor
Garcinia
/ chemistry
HT29 Cells
Humans
KB Cells
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Bark
/ chemistry
Plant Stems
/ chemistry
Prenylation
Spectrometry, Mass, Electrospray Ionization
Xanthones
/ chemistry
Journal
Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882
Informations de publication
Date de publication:
24 05 2019
24 05 2019
Historique:
pubmed:
13
4
2019
medline:
29
8
2020
entrez:
13
4
2019
Statut:
ppublish
Résumé
Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC
Identifiants
pubmed: 30978023
doi: 10.1021/acs.jnatprod.9b00046
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Xanthones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM