In vivo assembly of eukaryotic signal recognition particle: A still enigmatic process involving the SMN complex.
Assembly factors
Nucleolus
Ribonucleoprotein Particle
SMN complex
Signal recognition particle
Journal
Biochimie
ISSN: 1638-6183
Titre abrégé: Biochimie
Pays: France
ID NLM: 1264604
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
04
02
2019
accepted:
07
04
2019
pubmed:
13
4
2019
medline:
31
12
2019
entrez:
13
4
2019
Statut:
ppublish
Résumé
The signal recognition particle (SRP) is a universally conserved non-coding ribonucleoprotein complex that is essential for targeting transmembrane and secretory proteins to the endoplasmic reticulum. Its composition and size varied during evolution. In mammals, SRP contains one RNA molecule, 7SL RNA, and six proteins: SRP9, 14, 19, 54, 68 and 72. Despite a very good understanding of the SRP structure and of the SRP assembly in vitro, how SRP is assembled in vivo remains largely enigmatic. Here we review current knowledge on how the 7SL RNA is assembled with core proteins to form functional RNP particles in cells. SRP biogenesis is believed to take place both in the nucleolus and in the cytoplasm and to rely on the survival of motor neuron complex, whose defect leads to spinal muscular atrophy.
Identifiants
pubmed: 30978374
pii: S0300-9084(19)30109-9
doi: 10.1016/j.biochi.2019.04.007
pii:
doi:
Substances chimiques
7SL RNA
0
RNA, Small Cytoplasmic
0
SMN Complex Proteins
0
Signal Recognition Particle
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-104Informations de copyright
Copyright © 2019 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.