questionsmedicales.fr
Cellules
Structures cellulaires
Espace intracellulaire
Structures nucléaires
Espace intranucléaire
Espace intranucléaire : Questions médicales fréquentes
Diagnostic
5
Imagerie par résonance magnétique
Cytologie
Microscopie électronique
Analyse de l'ADN
Anomalies chromosomiques
Pathologie nucléaire
Évaluation génétique
Mutations
Protéines nucléaires
Marqueurs biologiques
Symptômes
5
Troubles cellulaires
Dysfonctionnements métaboliques
Anomalies nucléaires
Douleur
Cancer
Maladies génétiques
Symptômes neurologiques
Anomalies intranucléaires
Prévention
5
Alimentation
Antioxydants
Tabagisme
Facteurs de risque
Traitements
5
Chimiothérapie
Radiothérapie
Thérapie génique
Anomalies nucléaires
Médicaments ciblés
Maladies spécifiques
Traitement personnalisé
Profil génétique
Traitements expérimentaux
Évaluation clinique
Complications
5
Cancers
Maladies génétiques
Infections
Système immunitaire
Récidive
Anomalies nucléaires
Complications réversibles
Traitement
Qualité de vie
Complications
Facteurs de risque
5
Agents cancérigènes
Antécédents familiaux
Facteurs environnementaux
Toxines
Infections virales
Facteurs de risque
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"text": "Oui, surveiller des signes de cancer ou de maladies génétiques est crucial."
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"text": "Oui, les symptômes peuvent varier en fonction de l'âge et de l'état de santé général."
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"text": "Oui, une alimentation riche en antioxydants peut réduire le risque d'anomalies nucléaires."
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"text": "Oui, des traitements expérimentaux sont en cours d'évaluation pour certaines conditions."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des cancers, des maladies génétiques et des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Les anomalies nucléaires peuvent-elles entraîner des infections ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent affaiblir le système immunitaire, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de récidive ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent avoir un risque de récidive après traitement."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent significativement affecter la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'exposition à des agents cancérigènes, le tabagisme et des antécédents familiaux."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'anomalies nucléaires augmente avec l'âge."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut augmenter le risque d'anomalies."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections virales peuvent être des facteurs de risque pour des anomalies nucléaires."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 18/07/2026
Contenu vérifié selon les dernières recommandations médicales
6 publications dans cette catégorie
Affiliations :
Department of Neurology, The First Affiliated Hospital of Nanchang University, Yong Wai Zheng Street 17, Nanchang, 330006, Jiangxi Province, China. hongdaojun@hotmail.com.
6 publications dans cette catégorie
Affiliations :
Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China. haochen-2008@hotmail.com.
5 publications dans cette catégorie
Affiliations :
Department of Neurology, National Hospital Organization Suzuka National Hospital.
Publications dans "Espace intranucléaire" :
4 publications dans cette catégorie
Affiliations :
Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Department of Neurology, Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Publications dans "Espace intranucléaire" :
4 publications dans cette catégorie
Affiliations :
Department of Neurology (H.T., A.W., S.L., Y.P., S.N., H.P., B.C., X.W., Z.Z.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H.T., A.W., Yumei Zhang, S.L., Y.P., S.N., H.P., B.C., X.W., G.D., Z.Z.), Beijing; Monogenic Disease Research Center for Neurological Disorders (Yumei Zhang), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (K.L.), Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Department of Neurology (G.Z.), Huashan Hospital, Shanghai Medical College, Fudan University; Department of Neurology (M.W.), The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou; Department of Neurology (G.W.), Lanzhou University Second Hospital; Department of Pathology (G.D.), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (W.L.), Army Medical Center of People's Liberation Army, Chongqing; Department of Neurology (Ying Zhang), The First People's Hospital of Shangqiu; Department of Neurology (S.G.), The First Affiliated Hospital of Xinxiang Medical University; Department of Neurology (X.L.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan; Department of Neurology (M.L.), The First People's Hospital of Huaihua City; Department of Neurology (H.L.), The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou; Department of Neurology (M.H.), Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan; and Department of Neurology (W.C.), First Affiliated Hospital of Wenzhou Medical University, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China. cuiguiyun56@gmail.com.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Peking University First Hospital, Beijing, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Peking University First Hospital, Beijing, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology (H.T., A.W., S.L., Y.P., S.N., H.P., B.C., X.W., Z.Z.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H.T., A.W., Yumei Zhang, S.L., Y.P., S.N., H.P., B.C., X.W., G.D., Z.Z.), Beijing; Monogenic Disease Research Center for Neurological Disorders (Yumei Zhang), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (K.L.), Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Department of Neurology (G.Z.), Huashan Hospital, Shanghai Medical College, Fudan University; Department of Neurology (M.W.), The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou; Department of Neurology (G.W.), Lanzhou University Second Hospital; Department of Pathology (G.D.), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (W.L.), Army Medical Center of People's Liberation Army, Chongqing; Department of Neurology (Ying Zhang), The First People's Hospital of Shangqiu; Department of Neurology (S.G.), The First Affiliated Hospital of Xinxiang Medical University; Department of Neurology (X.L.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan; Department of Neurology (M.L.), The First People's Hospital of Huaihua City; Department of Neurology (H.L.), The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou; Department of Neurology (M.H.), Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan; and Department of Neurology (W.C.), First Affiliated Hospital of Wenzhou Medical University, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology (H.T., A.W., S.L., Y.P., S.N., H.P., B.C., X.W., Z.Z.), Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases (H.T., A.W., Yumei Zhang, S.L., Y.P., S.N., H.P., B.C., X.W., G.D., Z.Z.), Beijing; Monogenic Disease Research Center for Neurological Disorders (Yumei Zhang), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (K.L.), Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences; Department of Neurology (G.Z.), Huashan Hospital, Shanghai Medical College, Fudan University; Department of Neurology (M.W.), The First Affiliated Hospital of Fujian Medical University, Fujian Medical University, Fuzhou; Department of Neurology (G.W.), Lanzhou University Second Hospital; Department of Pathology (G.D.), Beijing Tiantan Hospital, Capital Medical University; Department of Neurology (W.L.), Army Medical Center of People's Liberation Army, Chongqing; Department of Neurology (Ying Zhang), The First People's Hospital of Shangqiu; Department of Neurology (S.G.), The First Affiliated Hospital of Xinxiang Medical University; Department of Neurology (X.L.), Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan; Department of Neurology (M.L.), The First People's Hospital of Huaihua City; Department of Neurology (H.L.), The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou; Department of Neurology (M.H.), Hubei Provincial Hospital of Integrated Chinese & Western Medicine, Wuhan; and Department of Neurology (W.C.), First Affiliated Hospital of Wenzhou Medical University, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Central South University, Changsha, Hunan, China.
Engineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, Hunan, China.
Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China.
Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, Hunan, China.
Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Japan.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Xuhui District, 600 Yishan Road, Shanghai, 200233, China.
Publications dans "Espace intranucléaire" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Xuhui District, 600 Yishan Road, Shanghai, 200233, China.
Publications dans "Espace intranucléaire" :
2 publications dans cette catégorie
Affiliations :
Department of Laboratory Medicine, NCNP, Kodaira, Japan.
Publications dans "Espace intranucléaire" :
2 publications dans cette catégorie
Affiliations :
Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan.
Medical Genome Center, NCNP, Kodaira, Japan.
Publications dans "Espace intranucléaire" :
2 publications dans cette catégorie
Affiliations :
School of Materials Science and Engineering, Wuhan University of Technology, 122 Luoshi Road, Wuhan, Hubei, 430070, China.
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02454, USA.
Publications dans "Espace intranucléaire" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02454, USA.
Publications dans "Espace intranucléaire" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Brandeis University, 415 South Street, Waltham, MA, 02454, USA.
Publications dans "Espace intranucléaire" :
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease with variable clinical phenotypes. There is a considerable delay in the definite diagnosis, which primarily depends o...
Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder represented by eosinophilic intranuclear inclusions (EIIs) and GGC/CGG repeat expansion in the NOTCH2NLC gene. We report ...
The escalating impact of global warming on crop yield and quality poses a significant threat to future food supplies. Breeding heat-resistant crop varieties holds promise, but necessitates a deeper un...
Neuronal intranuclear inclusion disease (NIID) is an underdiagnosed neurodegenerative disorder caused by pathogenic GGC expansions in...
Neuronal intranuclear inclusion disease (NIID) exhibits diverse clinical manifestations. Our patient was a 64-year-old woman with bilateral ptosis as the chief complaint. She had bilateral miosis, and...
Neuronal intranuclear inclusion disease, caused by a GGC repeat expansion in the 5'-untranslated region of NOTCH2NLC, is a rare neurodegenerative condition with highly variable clinical manifestations...
The neutrophil-to-lymphocyte ratio (NLR) is a widely recognized marker of inflammation in peripheral blood. However, its specific role in neuronal intranuclear inclusion disease (NIID) has not been re...
A multicenter database was collected, including 157 NIID patients from seven hospitals (The Affiliated Hospital of Xuzhou Medical University, Yantai Yuhuangding Hospital, Tengzhou Central People's Hos...
NIID patients exhibited significantly higher NLR values compared to the healthy control group (p < 0.001). The plasma NLR levels in NIID patients showed a weak positive correlation with disease durati...
There is a significant association between NLR and NIID, suggesting a potential role of peripheral blood inflammation in the pathogenesis of NIID....
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease caused by a trinucleotide (CAG) repeat expansion in the ATXN1 gene. It is characterized by the presence of polyg...
Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease caused by the expansion of GGC repeats in the 5'-untranslated region (5'-UTR) of NOTCH2NLC. Although increasing evide...
Exome sequencing (ES) and nanopore long-read whole-genome sequencing (LR-WGS) were performed on the index case, followed by nanopore target sequencing using Cas9-mediated PCR-free enrichment and methy...
ES revealed no candidate variants; however, nanopore LR-WGS in the index case revealed expansion of short tandem repeats (STR) in NOTCH2NLC. Subsequent nanopore target sequencing using Cas9-mediated P...
This investigation expands the clinical spectrum of NIID, suggesting that STR expansion of NOTCH2NLC is a cause of renal diseases, including FSGS....
Over the last 30 years, despite considerable research and endeavors aimed at harnessing aptamers as pharmaceutical molecules, the progress in developing aptamer-based drugs has been falling short of e...