Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain.
GluD2
cerebellum
purkinje cells
staufen2
synaptogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
06
03
2019
revised:
02
04
2019
accepted:
08
04
2019
entrez:
14
4
2019
pubmed:
14
4
2019
medline:
17
8
2019
Statut:
epublish
Résumé
Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role of Stau2 in the regulation of its neuronal target mRNAs, with particular focus on the hippocampus. Here, we provide evidence for Stau2 expression and function in cerebellar Purkinje cells. We show that Stau2 downregulation (Stau2
Identifiants
pubmed: 30979012
pii: ijms20071797
doi: 10.3390/ijms20071797
pmc: PMC6480955
pii:
doi:
Substances chimiques
Nerve Tissue Proteins
0
RNA, Messenger
0
RNA-Binding Proteins
0
Receptors, Glutamate
0
glutamate receptor delta 2
0
stau2 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SPP1738
Organisme : Deutsche Forschungsgemeinschaft
ID : Kie 502/2-1
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR2333
Organisme : Deutsche Forschungsgemeinschaft
ID : Kie 502/3-1
Organisme : Friedrich-Baur-Stiftung
ID : 02/14
Organisme : Friedrich-Baur-Stiftung
ID : 02/16
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