Multiplexing of Theta and Alpha Rhythms in the Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information.
Adult
Alpha Rhythm
/ physiology
Amygdala
/ physiology
Discrimination, Psychological
Electrocorticography
Electroencephalography Phase Synchronization
Emotions
Female
Hippocampus
/ physiology
Humans
Male
Memory
Memory, Episodic
Middle Aged
Neural Pathways
/ physiology
Theta Rhythm
/ physiology
Young Adult
alpha
amygdala
emotional memory
hippocampus
memory generalization
oscillations
pattern separation
theta
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
22 05 2019
22 05 2019
Historique:
received:
25
06
2018
revised:
02
11
2018
accepted:
18
03
2019
pubmed:
14
4
2019
medline:
26
3
2020
entrez:
14
4
2019
Statut:
ppublish
Résumé
How do we remember emotional events? While emotion often leads to vivid recollection, the precision of emotional memories can be degraded, especially when discriminating among overlapping experiences in memory (i.e., pattern separation). Communication between the amygdala and the hippocampus has been proposed to support emotional memory, but the exact neural mechanisms remain unclear. Here, we used intracranial recordings in pre-surgical epilepsy patients to show that successful pattern separation of emotional stimuli is associated with theta band (3-7 Hz)-coordinated bidirectional interactions between the amygdala and the hippocampus. In contrast, discrimination errors (i.e., failure to discriminate similar stimuli) were associated with alpha band (7-13 Hz)-coordinated unidirectional influence from the amygdala to the hippocampus. These findings imply that alpha band synchrony may impair discrimination of similar emotional events via the amygdala-hippocampal directional coupling, which suggests a target for treatments of psychiatric conditions such as post-traumatic stress disorder, in which aversive experiences are often overgeneralized.
Identifiants
pubmed: 30979537
pii: S0896-6273(19)30288-0
doi: 10.1016/j.neuron.2019.03.025
pmc: PMC6605056
mid: NIHMS1027369
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
887-898.e5Subventions
Organisme : NIMH NIH HHS
ID : R01 MH102392
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS021135
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS021135
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS045540
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019. Published by Elsevier Inc.
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