Non-canonical B cell functions in transplantation.
Antibody-independent B cell functions
B cells
Lymphoid organogenesis
Regulatory B cells
T cell repertoire
Journal
Human immunology
ISSN: 1879-1166
Titre abrégé: Hum Immunol
Pays: United States
ID NLM: 8010936
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
29
11
2018
revised:
04
04
2019
accepted:
09
04
2019
pubmed:
14
4
2019
medline:
19
11
2019
entrez:
14
4
2019
Statut:
ppublish
Résumé
B cells are differentiated to recognize antigen and respond by producing antibodies. These activities, governed by recognition of ancillary signals, defend the individual against microorganisms and the products of microorganisms and constitute the canonical function of B cells. Despite the unique differentiation (e.g. recombination and mutation of immunoglobulin gene segments) toward this canonical function, B cells can provide other, "non-canonical" functions, such as facilitating of lymphoid organogenesis and remodeling and fashioning T cell repertoires and modifying T cell responses. Some non-canonical functions are exerted by antibodies, but most are mediated by other products and/or direct actions of B cells. The diverse set of non-canonical functions makes the B cell as much as any cell a central organizer of innate and adaptive immunity. However, the diverse products and actions also confound efforts to weigh the importance of individual non-canonical B cell functions. Here we shall describe the non-canonical functions of B cells and offer our perspective on how those functions converge in the development and governance of immunity, particularly immunity to transplants, and hurdles to advancing understanding of B cell functions in transplantation.
Identifiants
pubmed: 30980861
pii: S0198-8859(18)31086-3
doi: 10.1016/j.humimm.2019.04.006
pmc: PMC6544480
mid: NIHMS1527307
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-377Subventions
Organisme : NIAID NIH HHS
ID : R01 AI122369
Pays : United States
Organisme : NIH HHS
ID : R01 OD023138
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI123262
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
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