The negative effect of lipid challenge on autophagy inhibits T cell responses.
Animals
Autophagy
/ drug effects
CD4-Positive T-Lymphocytes
/ drug effects
Cell Proliferation
/ drug effects
Cytokines
/ metabolism
Diet, High-Fat
Down-Regulation
/ drug effects
Female
Homeostasis
/ drug effects
Humans
Lipids
/ pharmacology
Lymphocyte Activation
/ drug effects
Mice, Inbred C57BL
Obesity
/ immunology
Oleic Acid
/ pharmacology
Receptors, Antigen, T-Cell
/ metabolism
T-Lymphocytes
/ drug effects
Fatty acid
T cell
lipid stress
macroautophagy
obesity
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
pubmed:
16
4
2019
medline:
24
11
2020
entrez:
16
4
2019
Statut:
ppublish
Résumé
Obesity is associated with changes in the immune system that significantly hinder its ability to mount efficient immune responses. Previous studies have reported a dysregulation of immune responses caused by lipid challenge; however, the mechanisms underlying that dysregulation are still not completely understood. Autophagy is an essential catabolic process through which cellular components are degraded by the lysosomal machinery. In T cells, autophagy is an actively regulated process necessary to sustain homeostasis and activation. Here, we report that CD4
Identifiants
pubmed: 30982401
doi: 10.1080/15548627.2019.1606635
pmc: PMC6984598
doi:
Substances chimiques
Cytokines
0
Lipids
0
Receptors, Antigen, T-Cell
0
Oleic Acid
2UMI9U37CP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
223-238Subventions
Organisme : NIA NIH HHS
ID : R37 AG021904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045223
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI146180
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI113919
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG038072
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013330
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG031782
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007491
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137198
Pays : United States
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