Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.

Animals Biomarkers, Tumor / metabolism Breast Neoplasms / metabolism Cadherins / metabolism Carcinoma, Ductal, Breast / metabolism Carcinoma, Intraductal, Noninfiltrating / metabolism Carcinoma, Lobular / metabolism Cell Line, Tumor Extracellular Vesicles Female Humans Neoplasm Metastasis Rats Signal Transduction Tetraspanins / metabolism
Tspan8 beta-catenin signalling pathway breast cancer extracellular vesicles mesenchymal-epithelial transition metastases tetraspanins three-dimensional cell culture

Journal

The Journal of pathology
ISSN: 1096-9896
Titre abrégé: J Pathol
Pays: England
ID NLM: 0204634

Informations de publication

Date de publication:
08 2019
Historique:
received: 05 03 2018
revised: 23 03 2019
accepted: 27 03 2019
pubmed: 16 4 2019
medline: 16 4 2020
entrez: 16 4 2019
Statut: ppublish

Résumé

Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in the majority of human primary breast cancer lesions and metastases in the brain, bone, lung, and liver. In a syngeneic rat breast cancer model, Tspan8

Identifiants

DOI: 10.1002/path.5281 PMID: 30982971 PMC: PMC6771825
pubmed: 30982971
doi: 10.1002/path.5281
pmc: PMC6771825
doi:

Substances chimiques

Biomarkers, Tumor 0
Cadherins 0
TSPAN8 protein, human 0
Tetraspanins 0
Tspan8 protein, rat 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

421-437

Informations de copyright

© 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Références

Clin Cancer Res. 2015 Aug 15;21(16):3667-77
pubmed: 25904749
Radiat Oncol. 2010 Sep 17;5:82
pubmed: 20849637
Acta Pharmacol Sin. 2007 Jan;28(1):66-72
pubmed: 17184584
Oncotarget. 2014 Dec 15;5(23):12203-17
pubmed: 25356755
Biochem Biophys Res Commun. 2015 Mar 13;458(3):476-482
pubmed: 25680464
J Cell Sci. 2011 Apr 15;124(Pt 8):1183-93
pubmed: 21444749
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Nat Rev Cancer. 2012 May 11;12(6):425-36
pubmed: 22576165
Biol Chem. 2016 Sep 1;397(9):857-69
pubmed: 27180358
Clin Exp Metastasis. 2015 Oct;32(7):717-27
pubmed: 26319493
Exp Cell Res. 1983 Sep;147(2):255-67
pubmed: 6688589
Oncogenesis. 2017 Apr 3;6(4):e309
pubmed: 28368391
Cancer Cell. 2012 Dec 11;22(6):699-701
pubmed: 23238008
Nat Cell Biol. 2017 Mar;19(3):164-176
pubmed: 28192422
Sci Rep. 2016 Sep 14;6:33376
pubmed: 27624978
J Clin Invest. 2009 Jun;119(6):1420-8
pubmed: 19487818
Biochem Biophys Res Commun. 2015 Dec 25;468(4):774-80
pubmed: 26562525
Oncogene. 2017 Jan 26;36(4):446-457
pubmed: 27375018
Oncogene. 2016 Aug 25;35(34):4540-8
pubmed: 26804173
J Cell Sci. 2003 Nov 1;116(Pt 21):4373-90
pubmed: 13130099
Am J Pathol. 2017 Jan;187(1):146-155
pubmed: 27855278
Nat Rev Cancer. 2009 Jan;9(1):40-55
pubmed: 19078974
Br J Cancer. 2011 Jan 4;104(1):155-65
pubmed: 21081927
Cancer Sci. 2017 Sep;108(9):1769-1777
pubmed: 28699254
BMC Cancer. 2016 Mar 18;16:236
pubmed: 26988558
PLoS One. 2014 Mar 20;9(3):e92317
pubmed: 24651522
J Cancer. 2017 Sep 12;8(16):3131-3141
pubmed: 29158785
Nat Med. 2017 Oct 6;23(10):1124-1134
pubmed: 28985214
Semin Cell Dev Biol. 2009 Oct;20(8):931-41
pubmed: 19682592
Nature. 2015 Nov 26;527(7579):525-530
pubmed: 26560028
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Int J Biochem Cell Biol. 2011 Jan;43(1):106-19
pubmed: 20937409
Mol Cancer. 2010 Jul 07;9:179
pubmed: 20609236
J Cell Biol. 1998 Apr 6;141(1):267-80
pubmed: 9531564
Mol Biol Cell. 2015 Sep 15;26(18):3190-204
pubmed: 26371081
J Surg Res. 2010 Oct;163(2):235-43
pubmed: 20691996
Lab Chip. 2017 Dec 19;18(1):179-189
pubmed: 29211089
Front Cell Dev Biol. 2017 Apr 06;5:34
pubmed: 28428953
J Cell Sci. 2014 Sep 1;127(Pt 17):3641-8
pubmed: 25128561
Mol Biol Cell. 2007 May;18(5):1634-44
pubmed: 17314408
FEBS Lett. 2015 Jun 22;589(14):1577-87
pubmed: 25979173
Int J Mol Sci. 2015 Mar 09;16(3):5363-74
pubmed: 25761241
J Hepatol. 2001 Nov;35(5):637-42
pubmed: 11690710
J Pathol. 2011 Jan;223(1):4-14
pubmed: 20938929
Nature. 2015 Nov 26;527(7579):472-6
pubmed: 26560033
Eur J Cancer. 2010 May;46(7):1181-8
pubmed: 20304630
Cancer Res. 2010 Oct 1;70(19):7674-83
pubmed: 20858717
Nat Med. 2012 Jun;18(6):883-91
pubmed: 22635005
Cancer Res. 2017 Nov 1;77(21):5900-5912
pubmed: 28883001
J Bone Miner Res. 2001 Aug;16(8):1486-95
pubmed: 11499871
Semin Cancer Biol. 2015 Dec;35:85-95
pubmed: 26319607
Cancer Res. 2010 Feb 15;70(4):1668-78
pubmed: 20124479
J Transl Med. 2011 Jun 08;9:86
pubmed: 21651777
Nat Rev Cancer. 2017 May;17(5):302-317
pubmed: 28303905
Pathol Oncol Res. 2018 Nov 16;:null
pubmed: 30443844
Oncotarget. 2017 Mar 28;8(13):22034-22047
pubmed: 28423546
Cancer Res. 2008 May 1;68(9):3204-13
pubmed: 18451146
Int J Mol Med. 2015 Mar;35(3):798-802
pubmed: 25592989
Nature. 2013 Sep 19;501(7467):328-37
pubmed: 24048065
Nat Rev Cancer. 2014 Jan;14(1):49-60
pubmed: 24505619
Nat Cell Biol. 2015 Jun;17(6):816-26
pubmed: 25985394

Auteurs

Maren Voglstaetter (M)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Andreas R Thomsen (AR)

Department of Radiation Oncology, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany.
German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.

Jerome Nouvel (J)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Arend Koch (A)

Institute of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Paul Jank (P)

Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Elena Grueso Navarro (EG)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Tanja Gainey-Schleicher (T)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Richa Khanduri (R)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Andrea Groß (A)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Florian Rossner (F)

Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Carina Blaue (C)

DFG-Center for Functional Nanostructures, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Clemens M Franz (CM)

DFG-Center for Functional Nanostructures, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Marina Veil (M)

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Gerhard Puetz (G)

Institute of Clinical Chemistry and Laboratory Medicine, University of Freiburg, Freiburg im Breisgau, Germany.

Andreas Hippe (A)

Department of Dermatology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.

Jochen Dindorf (J)

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.
Translational Research Center, Friedrich-Alexander-University of Erlangen-Nuernberg, Erlangen, Germany.

Jubin Kashef (J)

Institute for Photon Science and Synchrotron Radiation, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany.

Wilko Thiele (W)

Medical Faculty, University of Heidelberg, Mannheim, Germany.

Bernhard Homey (B)

Department of Dermatology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.

Celine Greco (C)

UMR-S935, Inserm, Université Paris Sud, Université Paris Saclay, Villejuif, France.
Department of Pain Management and Palliative Care, Necker Hospital, Paris, France.

Claude Boucheix (C)

UMR-S935, Inserm, Université Paris Sud, Université Paris Saclay, Villejuif, France.
Department of Pain Management and Palliative Care, Necker Hospital, Paris, France.

Andreas Baur (A)

Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.
Translational Research Center, Friedrich-Alexander-University of Erlangen-Nuernberg, Erlangen, Germany.

Thalia Erbes (T)

Department of Gynecology and Obstetrics, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Cornelius F Waller (CF)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Marie Follo (M)

Department of Medicine I, Medical Center, University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Ghamartaj Hossein (G)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Animal Physiology, Laboratory of Developmental Biology, University of Tehran, Tehran, Iran.

Christine Sers (C)

Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.

Jonathan Sleeman (J)

Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Medical Faculty, University of Heidelberg, Mannheim, Germany.

Irina Nazarenko (I)

Institute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID: 0000-0002-2633-1161

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Cadhérines › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Carcinome canalaire du sein › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs canalaires, lobulaires et médullaires › Carcinome intracanalaire non infiltrant › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Carcinome lobulaire › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Tspan8 is expressed in breast cancer and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Tétraspanines › Tspan8 is expressed in breast cancer and...