Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis.

Mechanistic Target of Rapamycin Complex 1 / metabolism Mechanistic Target of Rapamycin Complex 2 / metabolism Proteomics Saccharomyces cerevisiae / pathogenicity Saccharomyces cerevisiae Proteins / metabolism Signal Transduction TOR Serine-Threonine Kinases / metabolism
biomarkers caffeine drug targets multiomics network-based analysis target of rapamycin (TOR) signaling

Journal

Omics : a journal of integrative biology
ISSN: 1557-8100
Titre abrégé: OMICS
Pays: United States
ID NLM: 101131135

Informations de publication

Date de publication:
05 2019
Historique:
pubmed: 16 4 2019
medline: 14 4 2020
entrez: 16 4 2019
Statut: ppublish

Résumé

Target of rapamycin (TOR) is a major signaling pathway and regulator of cell growth. TOR serves as a hub of many signaling routes, and is implicated in the pathophysiology of numerous human diseases, including cancer, diabetes, and neurodegeneration. Therefore, elucidation of unknown components of TOR signaling that could serve as potential biomarkers and drug targets has a great clinical importance. In this study, our aim is to integrate transcriptomics, interactomics, and regulomics data in

Identifiants

DOI: 10.1089/omi.2019.0021 PMID: 30985253
pubmed: 30985253
doi: 10.1089/omi.2019.0021
doi:

Substances chimiques

Saccharomyces cerevisiae Proteins 0
Mechanistic Target of Rapamycin Complex 1 EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 2 EC 2.7.11.1
TOR Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

274-284

Auteurs

Elif Dereli Eke (E)

1 Department of Information Engineering, University of Padua, Padua, Italy.
2 Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.

Kazim Yalcin Arga (KY)

3 Department of Bioengineering, Marmara University, Istanbul, Turkey.

Duygu Dikicioglu (D)

2 Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.
4 Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.

Serpil Eraslan (S)

2 Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.
5 Diagnostic Centre for Genetic Diseases, Koc University Hospital, Istanbul, Turkey.

Emir Erkol (E)

6 Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

Arzu Celik (A)

6 Department of Molecular Biology and Genetics, Bogazici University, Istanbul, Turkey.

Betul Kirdar (B)

2 Department of Chemical Engineering, Bogazici University, Istanbul, Turkey.

Barbara Di Camillo (B)

1 Department of Information Engineering, University of Padua, Padua, Italy.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-1 cible mécanistique de la rapamycine › Identification of Novel Components of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Complexe-2 cible mécanistique de la rapamycine › Identification of Novel Components of...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Identification of Novel Components of...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Identification of Novel Components of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › Identification of Novel Components of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Identification of Novel Components of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Sérine-thréonine kinases TOR › Identification of Novel Components of...