The absolute counts of peripheral T lymphocyte subsets in patient with ankylosing spondylitis and the effect of low-dose interleukin-2.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
entrez:
16
4
2019
pubmed:
16
4
2019
medline:
23
4
2019
Statut:
ppublish
Résumé
The aim of this analysis is to investigate the level of T cell subsets in ankylosing spondylitis (AS) and the effect of low-dose interleukin 2 (IL-2).This is a retrospective cohort study, we collected basic information, inflammatory markers, BASDAI scores, and T lymphocyte subsets of peripheral blood in patients with AS, baseline analysis, correlation analysis and comparative analysis before and after treatment were performed.Data from 73 patients (of these, 36 patients were treated with IL-2) and 85 the health were included. The absolute numbers of peripheral CD4 Treg and CD8 Treg cells were lower, while the Th17 cell number and the ratio of Th17/CD4 Treg and CD4/CD8 Treg were higher. The CD4 Treg levels and the ratio of Th17/CD4 Tregs were correlated with BASDAI. The CD4 Treg, CD8 Treg, and Th17 cells were increased after treatment with IL-2 and the ratio of Th17/CD4 Treg was decreased.Increase in ratio of Th17/CD4 Treg involved in the occurrence of AS. At the same time, low-dose IL-2 could decrease the ratio of Th17/CD4 Treg in short time, low-dose IL-2 can be used to treat autoimmune diseases to avoid adverse reactions caused by immunosuppressants. Further clinical study is needed on the efficacy of IL-2.
Identifiants
pubmed: 30985663
doi: 10.1097/MD.0000000000015094
pii: 00005792-201904120-00024
pmc: PMC6485794
doi:
Substances chimiques
Immunologic Factors
0
Interleukin-2
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15094Références
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