A validated RP-HPLC method for the evaluation of the influence of grapefruit juice on liver S9 activation of sacubitril.
Aminobutyrates
/ pharmacokinetics
Animals
Biphenyl Compounds
Chromatography, High Pressure Liquid
/ methods
Citrus paradisi
/ chemistry
Drug Combinations
Fruit and Vegetable Juices
Limit of Detection
Linear Models
Microsomes, Liver
/ drug effects
Plant Extracts
/ pharmacokinetics
Rats
Reproducibility of Results
Tetrazoles
/ pharmacokinetics
Valsartan
RP-HPLC
esterase
grapefruit juice
interaction
sacubitril
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
12
12
2018
revised:
30
03
2019
accepted:
05
04
2019
pubmed:
16
4
2019
medline:
6
8
2019
entrez:
16
4
2019
Statut:
ppublish
Résumé
Grapefruit juice inhibits esterase enzyme. Therefore, a possible interaction with ester prodrugs should be taken into consideration. In this study, the influence of grapefruit juice on sacubitril (SAC) rat liver S9 activation by esterase enzyme was evaluated. An RP-HPLC method was developed and validated for estimation of SAC in rat liver S9 fraction using a C
Substances chimiques
Aminobutyrates
0
Biphenyl Compounds
0
Drug Combinations
0
Plant Extracts
0
Tetrazoles
0
Valsartan
80M03YXJ7I
sacubitril and valsartan sodium hydrate drug combination
WB8FT61183
Types de publication
Journal Article
Langues
eng
Pagination
e4553Informations de copyright
© 2019 John Wiley & Sons, Ltd.