No correlation between Torque Teno virus viral load and BK virus replication after kidney transplantation.
Adult
BK Virus
/ drug effects
Biomarkers
/ blood
DNA, Viral
/ blood
Female
Humans
Immunosuppression Therapy
Immunosuppressive Agents
/ therapeutic use
Kidney Transplantation
/ adverse effects
Male
Middle Aged
Retrospective Studies
Risk Factors
Torque teno virus
/ drug effects
Viral Load
/ drug effects
Virus Replication
/ drug effects
BK virus
Immunosuppression level
Kidney transplantation
Torque Teno virus
Journal
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
ISSN: 1873-5967
Titre abrégé: J Clin Virol
Pays: Netherlands
ID NLM: 9815671
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
11
02
2019
revised:
20
03
2019
accepted:
30
03
2019
pubmed:
16
4
2019
medline:
19
6
2020
entrez:
16
4
2019
Statut:
ppublish
Résumé
Assessment of the intensity of immunosuppression in transplant recipients to estimate the risk of rejection and infection is not entirely satisfactory at the present time. Determination of Torque teno virus (TTV) viral load appears to be a promising tool in this setting. We evaluated the level of replication and kinetics of TTV during the first three months after kidney transplantation compared to BK virus replication. In a retrospective cohort of 116 renal transplant recipients, TTV viral load gradually increased during the first three months post-transplantation with no significant difference or discriminatory threshold between patients with and without BK virus replication. However, the level of TTV replication appeared to be indirectly related to the risk of BK virus replication, particularly according to the induction treatment used (antithymocyte globulin: ATG or basiliximab). Among patients receiving ATG, those receiving cyclosporine had significantly lower TTV viral loads (p < 0.01) with threefold lower reactivation of BKPyV (13 vs 37%) 3 months post-transplantation. Similarly, among the women in our cohort, TTV viral load was significantly higher in women receiving ATG (6.58 ± 1.57 versus 4.62 ± 2.0 log The multiparametric variation of TTV viral load does not appear to be individually appropriate for the early detection or monitoring of possible post-transplant BKPyV virus reactivation in renal transplant recipients.
Sections du résumé
BACKGROUND
Assessment of the intensity of immunosuppression in transplant recipients to estimate the risk of rejection and infection is not entirely satisfactory at the present time. Determination of Torque teno virus (TTV) viral load appears to be a promising tool in this setting.
OBJECTIVES
We evaluated the level of replication and kinetics of TTV during the first three months after kidney transplantation compared to BK virus replication.
RESULTS
In a retrospective cohort of 116 renal transplant recipients, TTV viral load gradually increased during the first three months post-transplantation with no significant difference or discriminatory threshold between patients with and without BK virus replication. However, the level of TTV replication appeared to be indirectly related to the risk of BK virus replication, particularly according to the induction treatment used (antithymocyte globulin: ATG or basiliximab). Among patients receiving ATG, those receiving cyclosporine had significantly lower TTV viral loads (p < 0.01) with threefold lower reactivation of BKPyV (13 vs 37%) 3 months post-transplantation. Similarly, among the women in our cohort, TTV viral load was significantly higher in women receiving ATG (6.58 ± 1.57 versus 4.62 ± 2.0 log
CONCLUSION
The multiparametric variation of TTV viral load does not appear to be individually appropriate for the early detection or monitoring of possible post-transplant BKPyV virus reactivation in renal transplant recipients.
Identifiants
pubmed: 30986626
pii: S1386-6532(19)30074-5
doi: 10.1016/j.jcv.2019.03.018
pii:
doi:
Substances chimiques
Biomarkers
0
DNA, Viral
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4-6Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.