Increased plasma concentration of 4-pyridone-3-carboxamide-1-ß-D-ribonucleoside (4PYR) in lung cancer. Preliminary studies.
1-methylnicotinamide
4-pyridone-3-carboxamide-1-β-D-ribonucleoside
Nicotinamide
endothelium
lung cancer
Journal
Nucleosides, nucleotides & nucleic acids
ISSN: 1532-2335
Titre abrégé: Nucleosides Nucleotides Nucleic Acids
Pays: United States
ID NLM: 100892832
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
17
4
2019
medline:
20
9
2019
entrez:
17
4
2019
Statut:
ppublish
Résumé
4-pyridone-3-carboxamide-1-β-D-ribonucleoside (4PYR) is a new nicotinamide derivative, which is potentially toxic to the endothelium. Dysfunction of the endothelium promotes cancer cell proliferation, invasiveness, and inflammatory signaling. The aim of this study was to analyze 4PYR concentration in the plasma of lung cancer patients and its relationship to other known biochemical parameters associated with the endothelium function. The concentration of 4PYR, nicotinamide, 1-methylnicotinamide (MNA), amino acids, and their derivatives were measured in samples obtained from patients with primary squamous cell carcinoma (
Identifiants
pubmed: 30990116
doi: 10.1080/15257770.2019.1600705
doi:
Substances chimiques
4-pyridone-3-carboxamide-1-ribonucleoside
0
Biomarkers, Tumor
0
Nucleosides
0
Pyridones
0
Niacinamide
25X51I8RD4
N,N-dimethylarginine
63CV1GEK3Y
Arginine
94ZLA3W45F
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM